ENSMUSG00000028657


Mus musculus

Features
Gene ID: ENSMUSG00000028657
  
Biological name :Ppt1
  
Synonyms : O88531 / palmitoyl-protein thioesterase 1 / Ppt1
  
Possible biological names infered from orthology : P50897
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 122836242
Gene end: 122859175
  
Corresponding Affymetrix probe sets: 10507784 (MoGene1.0st)   1420015_s_at (Mouse Genome 430 2.0 Array)   1420016_at (Mouse Genome 430 2.0 Array)   1422467_at (Mouse Genome 430 2.0 Array)   1422468_at (Mouse Genome 430 2.0 Array)   1444884_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095512
Ensembl peptide - ENSMUSP00000113367
Ensembl peptide - ENSMUSP00000113258
Ensembl peptide - ENSMUSP00000030412
NCBI entrez gene - 19063     See in Manteia.
MGI - MGI:1298204
RefSeq - NM_008917
RefSeq Peptide - NP_032943
swissprot - O88531
swissprot - B1B0P9
swissprot - Q3U6J9
swissprot - B1B0P8
swissprot - F7CTA8
Ensembl - ENSMUSG00000028657
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppt1ENSDARG00000039980Danio rerio
 PPT1ENSGALG00000003936Gallus gallus
 PPT1ENSG00000131238Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppt2 / O35448 / Lysosomal thioesterase PPT2 / Q9UMR5* / PPT2-EGFL8* / palmitoyl-protein thioesterase 2* / PPT2-EGFL8 readthrough (NMD candidate)*ENSMUSG0000001547423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002472  Palmitoyl protein thioesterase
 IPR029058  Alpha/Beta hydrolase fold
 IPR030294  Palmitoyl-protein thioesterase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002084 protein depalmitoylation IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006907 pinocytosis IEA
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0007042 lysosomal lumen acidification IEA
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007625 grooming behavior IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0031579 membrane raft organization IEA
 biological_processGO:0032429 regulation of phospholipase A2 activity IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044257 cellular protein catabolic process IMP
 biological_processGO:0044265 cellular macromolecule catabolic process IMP
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0048549 positive regulation of pinocytosis IEA
 biological_processGO:0051181 cofactor transport IEA
 biological_processGO:0051186 cofactor metabolic process IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008474 palmitoyl-(protein) hydrolase activity IEA
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0098599 palmitoyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Rettm1Jmi/Ret+
Genetic Background: involves: 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rettm1Jmi/Ret+
Genetic Background: involves: 129X1/SvJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Rettm1Jmi/Ret+
Genetic Background: involves: 129X1/SvJ

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm1Jmi/Ret+
Genetic Background: involves: 129X1/SvJ

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002061 aggression-related behavior "domineering, assaultive or forceful physical action" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003246 loss of GABA neurons "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1.1Dprc/Ppt1tm1.1Dprc
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppt1tm1.1Dprc/Ppt1tm1.1Dprc
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0010762 abnormal microglial cell activation "any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppt1tm1.1Dprc/Ppt1tm1.1Dprc
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0012506 brain atrophy "acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ppt1tm1Aj/Ppt1tm1Aj
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gfaptm1Pkny/Gfaptm1Pkny,Ppt1tm1Hof/Ppt1tm1Hof,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ppt1tm1Hof/Ppt1tm1Hof
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0030278 thick neurocranium "increased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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