ENSMUSG00000028675


Mus musculus

Features
Gene ID: ENSMUSG00000028675
  
Biological name :Pnrc2
  
Synonyms : Pnrc2 / Proline-rich nuclear receptor coactivator 2 / Q9CR73
  
Possible biological names infered from orthology : Q9NPJ4
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 135870918
Gene end: 135873850
  
Corresponding Affymetrix probe sets: 10517421 (MoGene1.0st)   1416186_at (Mouse Genome 430 2.0 Array)   1416187_s_at (Mouse Genome 430 2.0 Array)   1438766_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030436
Ensembl peptide - ENSMUSP00000120788
Ensembl peptide - ENSMUSP00000136785
NCBI entrez gene - 52830     See in Manteia.
MGI - MGI:106512
RefSeq - NM_026383
RefSeq - XM_006539038
RefSeq - XM_006539039
RefSeq Peptide - NP_080659
swissprot - Q9CR73
swissprot - Z4YMU7
swissprot - J3QJZ8
Ensembl - ENSMUSG00000028675
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pnrc2ENSDARG00000053291Danio rerio
 PNRC2ENSGALG00000004122Gallus gallus
 PNRC2ENSG00000189266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pnrc1 / proline rich nuclear receptor coactivator 1 / Q12796*ENSMUSG0000004012839


Protein motifs (from Interpro)
Interpro ID Name
 IPR026780  Proline-rich nuclear receptor coactivator 1/2
 IPR026781  Proline-rich nuclear receptor coactivator 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr