| MP:0000750 | abnormal muscle regeneration | "inability or defects in ability to repair muscle after injuries" [J:42574] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0000752 | dystrophic muscle | "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000790 | abnormal stratification in cerebral cortex | "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000857 | abnormal cerebellar foliation | "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg
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| MP:0001330 | abnormal optic nerve morphology | "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0002106 | abnormal muscle physiology | "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0003044 | impaired basement membrane formation | "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0003084 | abnormal skeletal muscle fiber morphology | "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0003727 | abnormal retinal layer morphology | "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0004136 | abnormal tongue muscle morphology | "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0004272 | abnormal basement membrane morphology | "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0006309 | decreased retinal ganglion cell number | "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0008511 | thin retinal inner nuclear layer | "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0008515 | thin retinal outer nuclear layer | "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0009400 | decreased skeletal muscle fiber size | "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0009403 | increased variability of skeletal muscle fiber size | "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0009404 | centrally nucleated skeletal muscle fibers | "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0009406 | decreased skeletal muscle fiber number | "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0009410 | abnormal skeletal muscle satellite cell proliferation | "anomaly in the ability of unfused cells in skeltal muscle to undergo expansion by cell division, usually triggered by injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0010098 | abnormal retinal blood vessel pattern | "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg
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| MP:0010235 | abnormal retina inner limiting membrane morphology | "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myo5ad-n/Myo5ad-n
Genetic Background: B10.D2-H2d/nSnJ
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| MP:0010452 | retina microaneurysm | "focal dilation of arteriocapillary junctions in the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: B6.129P2-Irf7tm1Ttg
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac
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