ENSMUSG00000028832


Mus musculus

Features
Gene ID: ENSMUSG00000028832
  
Biological name :Stmn1
  
Synonyms : P54227 / stathmin 1 / Stmn1
  
Possible biological names infered from orthology : P16949
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 134468320
Gene end: 134473843
  
Corresponding Affymetrix probe sets: 10508986 (MoGene1.0st)   10513818 (MoGene1.0st)   1415849_s_at (Mouse Genome 430 2.0 Array)   1448113_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101493
Ensembl peptide - ENSMUSP00000119547
Ensembl peptide - ENSMUSP00000101494
Ensembl peptide - ENSMUSP00000030636
NCBI entrez gene - 16765     See in Manteia.
MGI - MGI:96739
RefSeq - NM_019641
RefSeq Peptide - NP_062615
swissprot - D3Z1Z8
swissprot - D3Z5N2
swissprot - P54227
swissprot - Q545B6
Ensembl - ENSMUSG00000028832
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stmn1aENSDARG00000004169Danio rerio
 stmn1bENSDARG00000033655Danio rerio
 STMN1ENSGALG00000001475Gallus gallus
 STMN1ENSG00000117632Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stmn2 / P55821 / stathmin-like 2 / Q93045* / stathmin 2*ENSMUSG0000002750063
Stmn4 / P63042 / stathmin-like 4 / Q9H169* / stathmin 4*ENSMUSG0000002204462
Stmn3 / O70166 / stathmin-like 3 / Q9NZ72* / stathmin 3*ENSMUSG0000002758157


Protein motifs (from Interpro)
Interpro ID Name
 IPR000956  Stathmin family
 IPR030514  Stathmin, conserved site
 IPR036002  Stathmin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0007019 microtubule depolymerization ISO
 biological_processGO:0007052 mitotic spindle organization ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031110 regulation of microtubule polymerization or depolymerization ISO
 biological_processGO:0031115 negative regulation of microtubule polymerization ISO
 biological_processGO:0035024 negative regulation of Rho protein signal transduction ISO
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway ISO
 biological_processGO:0051272 positive regulation of cellular component movement IGI
 biological_processGO:0051497 negative regulation of stress fiber assembly ISO
 biological_processGO:0061436 establishment of skin barrier ISO
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway ISO
 biological_processGO:1905098 negative regulation of guanyl-nucleotide exchange factor activity ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015631 tubulin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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