ENSMUSG00000028943


Mus musculus

Features
Gene ID: ENSMUSG00000028943
  
Biological name :Espn
  
Synonyms : Espin / Espn / Q9ET47
  
Possible biological names infered from orthology : B1AK53
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 152120331
Gene end: 152152371
  
Corresponding Affymetrix probe sets: 10518882 (MoGene1.0st)   1423005_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101278
Ensembl peptide - ENSMUSP00000147144
Ensembl peptide - ENSMUSP00000122464
Ensembl peptide - ENSMUSP00000101284
Ensembl peptide - ENSMUSP00000101283
Ensembl peptide - ENSMUSP00000101282
Ensembl peptide - ENSMUSP00000101281
Ensembl peptide - ENSMUSP00000101280
Ensembl peptide - ENSMUSP00000101279
Ensembl peptide - ENSMUSP00000030785
Ensembl peptide - ENSMUSP00000037982
Ensembl peptide - ENSMUSP00000065545
Ensembl peptide - ENSMUSP00000078951
Ensembl peptide - ENSMUSP00000081131
Ensembl peptide - ENSMUSP00000099485
NCBI entrez gene - 56226     See in Manteia.
MGI - MGI:1861630
RefSeq - XM_006539063
RefSeq - NM_019585
RefSeq - NM_207687
RefSeq - NM_207688
RefSeq - NM_207689
RefSeq - NM_207690
RefSeq - NM_207691
RefSeq - XM_006539059
RefSeq - XM_006539060
RefSeq - XM_006539061
RefSeq Peptide - NP_997574
RefSeq Peptide - NP_062531
RefSeq Peptide - NP_997570
RefSeq Peptide - NP_997571
RefSeq Peptide - NP_997572
RefSeq Peptide - NP_997573
swissprot - B1AWQ3
swissprot - B1AWQ1
swissprot - B1AWQ0
swissprot - B1AWP9
swissprot - B1AWP8
swissprot - Q9DD12
swissprot - Q9ET47
swissprot - B1AWQ4
swissprot - B1AWP7
swissprot - A0A140LJB0
Ensembl - ENSMUSG00000028943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 espnENSDARG00000076414Danio rerio
 ENSGALG00000038532Gallus gallus
 ESPNENSG00000187017Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Espnl / Q3UYR4 / Espin-like protein / Q6ZVH7* / espin like*ENSMUSG0000004951529
Q3V096 / Ankrd42 / Ankyrin repeat domain-containing protein 42 / Q8N9B4* / ankyrin repeat domain 42*ENSMUSG0000004134313
A2AS55 / Ankrd16 / Ankyrin repeat domain-containing protein 16 / Q6P6B7* / ankyrin repeat domain 16*ENSMUSG0000004790911


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR003124  WH2 domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR030233  Espin
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0030046 parallel actin filament bundle assembly IDA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IPI
 biological_processGO:0051494 negative regulation of cytoskeleton organization IDA
 biological_processGO:0051639 actin filament network formation NAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border ISS
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031941 filamentous actin IBA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032421 stereocilium bundle IDA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding ISS
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Zic3tm1Jwb/Y
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zic3tm1Jwb/Y
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espnje
Genetic Background: involves: fanciers stocks

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

 MP:0002630 abnormal endocochlear potential "alterations in the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [J:80917, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espnje
Genetic Background: involves: fanciers stocks

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Espnje/Espnje
Genetic Background: involves: fanciers stocks

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0002895 abnormal otolithic membrane "malformations of the gelatinous membrane surmounting the acoustic maculae of the saccule and utricle and containing minute calciferous particles (otoliths)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Espnje/Espnje
Genetic Background: involves: fanciers stocks

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003150 detached tectorial membrane "tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Espnje/Espnje
Genetic Background: involves: fanciers stocks

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004413 absent cochlear microphonics "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004416 absent cochlear nerve compound action potential "absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

 MP:0004523 decreased cochlear hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3tm1Jwb/Y
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004524 short cochlear hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3tm1Jwb/Y
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004525 thin cochlear hair cell stereocilia "reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zic3tm1Jwb/Y
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

 MP:0004586 pillar cell degeneration "degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcoln3Va-J/?
Genetic Background: involves: C57BL/6J * CZECHII/EiJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: CAST/EiJ * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: DBA/2J * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: BALB/cByJ * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: A/J * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: 129X1/SvJ * JE/LeJ

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3tm1Jwb/Y
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Tnfrsf25tm1Mjo/Tnfrsf25tm1Mjo
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0006335 abnormal hearing electrophysiology "anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0008763 abnormal mast cell degranulation "abnormalities in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Tg(Neurog3-cre/Esr1*)1Dam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0010323 retropulsion "a tendency to step or walk backwards" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Espnje/Espn+
Genetic Background: involves: fanciers dancing mouse

Allelic Composition: Espnje/Espnje
Genetic Background: JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: CZECHII/EiJ * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: CAST/EiJ * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: DBA/2J * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: BALB/cByJ * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: A/J * JE/LeJ

Allelic Composition: Espnje/Espnje
Genetic Background: involves: 129X1/SvJ * JE/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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