ENSMUSG00000049515


Mus musculus

Features
Gene ID: ENSMUSG00000049515
  
Biological name :Espnl
  
Synonyms : Espin-like protein / Espnl / Q3UYR4
  
Possible biological names infered from orthology : espin like / Q6ZVH7
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 91322075
Gene end: 91348306
  
Corresponding Affymetrix probe sets: 10348570 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000086294
Ensembl peptide - ENSMUSP00000135828
NCBI entrez gene - 227357     See in Manteia.
MGI - MGI:2685402
RefSeq - NM_001033292
RefSeq Peptide - NP_001028464
swissprot - H3BLK9
swissprot - Q3UYR4
Ensembl - ENSMUSG00000049515
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 espnlaENSDARG00000078211Danio rerio
 espnlbENSDARG00000093112Danio rerio
 ENSGALG00000000645Gallus gallus
 ESPNLENSG00000144488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Espn / Espin / Q9ET47 / B1AK53*ENSMUSG0000002894325
Q3V096 / Ankrd42 / Ankyrin repeat domain-containing protein 42 / Q8N9B4* / ankyrin repeat domain 42*ENSMUSG0000004134313
A2AS55 / Ankrd16 / Ankyrin repeat domain-containing protein 16 / Q6P6B7* / ankyrin repeat domain 16*ENSMUSG000000479099


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0051017 actin filament bundle assembly IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031941 filamentous actin IBA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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