ENSMUSG00000028960


Mus musculus

Features
Gene ID: ENSMUSG00000028960
  
Biological name :Ube4b
  
Synonyms : Q9ES00 / Ube4b / ubiquitination factor E4B
  
Possible biological names infered from orthology : O95155
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 149328416
Gene end: 149426749
  
Corresponding Affymetrix probe sets: 10518642 (MoGene1.0st)   1432499_a_at (Mouse Genome 430 2.0 Array)   1444465_at (Mouse Genome 430 2.0 Array)   1448410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099501
Ensembl peptide - ENSMUSP00000122020
Ensembl peptide - ENSMUSP00000134452
Ensembl peptide - ENSMUSP00000134556
NCBI entrez gene - 63958     See in Manteia.
MGI - MGI:1927086
RefSeq - XM_006539089
RefSeq - NM_022022
RefSeq - XM_006539088
RefSeq Peptide - NP_071305
swissprot - G3UZD6
swissprot - Q9ES00
swissprot - H7BXC2
swissprot - G3UZM6
Ensembl - ENSMUSG00000028960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube4bENSDARG00000037017Danio rerio
 UBE4BENSGALG00000002649Gallus gallus
 UBE4BENSG00000130939Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube4a / E9Q735 / ubiquitination factor E4A / Q14139*ENSMUSG0000005989021


Protein motifs (from Interpro)
Interpro ID Name
 IPR003613  U box domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019474  Ubiquitin conjugation factor E4, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0006457 protein folding NAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0044257 cellular protein catabolic process IMP
 biological_processGO:0051865 protein autoubiquitination IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IEA
 molecular_functionGO:0051082 unfolded protein binding NAS
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bmp2tm1Brd/Bmp2+,Tbx1tm1Pa/Tbx1+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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