ENSMUSG00000028963


Mus musculus

Features
Gene ID: ENSMUSG00000028963
  
Biological name :Uts2
  
Synonyms : Q9QZQ3 / urotensin 2 / Uts2
  
Possible biological names infered from orthology : O95399
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 150997097
Gene end: 151001810
  
Corresponding Affymetrix probe sets: 10510594 (MoGene1.0st)   1421799_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030803
NCBI entrez gene - 24111     See in Manteia.
MGI - MGI:1346329
RefSeq - NM_011910
RefSeq Peptide - NP_036040
swissprot - Q541G7
swissprot - Q9QZQ3
Ensembl - ENSMUSG00000028963
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UTS2ENSGALG00000000556Gallus gallus
 UTS2ENSG00000049247Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001483  Urotensin II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0003105 negative regulation of glomerular filtration IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness IEA
 biological_processGO:0032224 positive regulation of synaptic transmission, cholinergic IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035811 negative regulation of urine volume IEA
 biological_processGO:0035814 negative regulation of renal sodium excretion IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0010331 abnormal apolipoprotein level "anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039321 Uts2r / Q8VIH9 / urotensin 2 receptor / Q9UKP6*  / complex / reaction






 

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