ENSMUSG00000028967


Mus musculus

Features
Gene ID: ENSMUSG00000028967
  
Biological name :Errfi1
  
Synonyms : Errfi1 / Mus musculus ERBB receptor feedback inhibitor 1 (Errfi1), transcript variant 1, mRNA. / Q99JZ7
  
Possible biological names infered from orthology : ERBB receptor feedback inhibitor 1 / Q9UJM3
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 150853919
Gene end: 150868892
  
Corresponding Affymetrix probe sets: 10510574 (MoGene1.0st)   1416129_at (Mouse Genome 430 2.0 Array)   1419816_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030811
Ensembl peptide - ENSMUSP00000073285
NCBI entrez gene - 74155     See in Manteia.
MGI - MGI:1921405
RefSeq - XM_006539210
RefSeq - NM_001356323
RefSeq - NM_133753
RefSeq Peptide - NP_598514
RefSeq Peptide - NP_001343252
swissprot - Q3TK48
swissprot - Q99JZ7
Ensembl - ENSMUSG00000028967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 errfi1aENSDARG00000104039Danio rerio
 ERRFI1ENSGALG00000000535Gallus gallus
 ERRFI1ENSG00000116285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015116  Cdc42 binding domain-like
 IPR021619  Mig-6 domain
 IPR037085  Cdc42 binding domain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade ISO
 biological_processGO:0031953 negative regulation of protein autophosphorylation IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042536 negative regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0043589 skin morphogenesis IMP
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0060426 lung vasculature development IMP
 biological_processGO:0060428 lung epithelium development IMP
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071474 cellular hyperosmotic response IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031267 small GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr3tm2Wei/Fgfr3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0000574 abnormal foot pad morphology "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001272 increased metastatic potential 
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Ets2tm2Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ets2tm2Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0002676 uterine hyperplasia "increased size of the uterus due to increased cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Errfi1tm1Gvw/Errfi1tm1Gvw,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004868 endometrial carcinoma "malignant neoplasm arising from the endometrial tissue" [RGD:Rat Genome Database submission]
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005488 bronchial epithelial hyperplasia "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Errfi1tm1Kln/Errfi1tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0010887 pale lung "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0010910 bronchiolar epithelial hyperplasia "increased size, often due to increased epithelial cell number, of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0010942 abnormal respiratory epithelium morphology "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0010945 lung epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Errfi1tm1.1Jwj/Errfi1tm1.1Jwj
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0011692 increased chondrocyte number "greater number of polymorphic cells that form cartilage" [CL:0000138]
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Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(Col2a1-cre)1Asz/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0013401 increased endometrial gland number "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna]
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Allelic Composition: Errfi1tm1Jwj/Errfi1tm1Jwj,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030332 accelerated temporomandibular joint osteoarthritis "earlier onset or more rapid progression of a degenerative condition of the temporomandibular joint that results from breakdown of joint cartilage and underlying bone; erosive lesions and joint space narrowing usually indicate acute or early changes, whereas sclerosis, flattening, subchondral cysts, and osteophytes may indicate late changes" [http://www.sciencedirect.com/science/article/pii/S2319417016301536, MGI:anna]
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Allelic Composition: Casp3tm1Flv/Casp3tm1Flv,Casp6tm1Flv/Casp6tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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