ENSMUSG00000028980


Mus musculus

Features
Gene ID: ENSMUSG00000028980
  
Biological name :H6pd
  
Synonyms : H6pd / hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) / Q8CFX1
  
Possible biological names infered from orthology : O95479
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 149979475
Gene end: 150009023
  
Corresponding Affymetrix probe sets: 10518743 (MoGene1.0st)   1452145_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115647
Ensembl peptide - ENSMUSP00000030830
Ensembl peptide - ENSMUSP00000081134
NCBI entrez gene - 100198     See in Manteia.
MGI - MGI:2140356
RefSeq - XM_006538459
RefSeq - NM_001291004
RefSeq - NM_173371
RefSeq - XM_006538458
RefSeq Peptide - NP_001277933
RefSeq Peptide - NP_775547
swissprot - A2A7A8
swissprot - Q8CFX1
swissprot - A2A7A7
Ensembl - ENSMUSG00000028980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h6pdENSDARG00000060153Danio rerio
 H6PDENSGALG00000002492Gallus gallus
 H6PDENSG00000049239Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G6pd2 / G6PD* / P11413* / glucose-6-phosphate dehydrogenase*ENSMUSG0000008999218
G6pdx / Q00612 / Glucose-6-phosphate 1-dehydrogenase X / G6PD* / P11413* / glucose-6-phosphate dehydrogenase*ENSMUSG0000003140018


Protein motifs (from Interpro)
Interpro ID Name
 IPR001282  Glucose-6-phosphate dehydrogenase
 IPR005900  6-phosphogluconolactonase, DevB-type
 IPR006148  Glucosamine/galactosamine-6-phosphate isomerase
 IPR019796  Glucose-6-phosphate dehydrogenase, active site
 IPR022674  Glucose-6-phosphate dehydrogenase, NAD-binding
 IPR022675  Glucose-6-phosphate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily
 IPR037171  NagB/RpiA transferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006098 pentose-phosphate shunt IEA
 biological_processGO:0006739 NADP metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097305 response to alcohol IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004345 glucose-6-phosphate dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017057 6-phosphogluconolactonase activity IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0047936 glucose 1-dehydrogenase [NAD(P)] activity IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: H6pdtm1a(EUCOMM)Wtsi/H6pdtm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-H6pdtm1a(EUCOMM)Wtsi/Ics

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst
Genetic Background: involves: 129P2/OlaHsd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst
Genetic Background: involves: 129P2/OlaHsd

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009428 decreased tibialis anterior weight "redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt27stpm/Krt27stpm
Genetic Background: RHJ/LeJ-Krt27stpm/GrsrJ

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst,Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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