ENSMUSG00000031400


Mus musculus

Features
Gene ID: ENSMUSG00000031400
  
Biological name :G6pdx
  
Synonyms : G6pdx / Glucose-6-phosphate 1-dehydrogenase X / Q00612
  
Possible biological names infered from orthology : G6PD / glucose-6-phosphate dehydrogenase / P11413
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 74409483
Gene end: 74429194
  
Corresponding Affymetrix probe sets: 10605338 (MoGene1.0st)   1422327_s_at (Mouse Genome 430 2.0 Array)   1444501_at (Mouse Genome 430 2.0 Array)   1448354_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115915
Ensembl peptide - ENSMUSP00000004327
NCBI entrez gene - 14381     See in Manteia.
MGI - MGI:105979
RefSeq - NM_008062
RefSeq Peptide - NP_032088
swissprot - A3KG36
swissprot - Q00612
swissprot - Q790Y8
Ensembl - ENSMUSG00000031400
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 g6pdENSDARG00000071065Danio rerio
 G6PDENSG00000160211Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G6pd2 / G6PD* / P11413* / glucose-6-phosphate dehydrogenase*ENSMUSG0000008999292
H6pd / Q8CFX1 / hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) / O95479*ENSMUSG0000002898028


Protein motifs (from Interpro)
Interpro ID Name
 IPR001282  Glucose-6-phosphate dehydrogenase
 IPR019796  Glucose-6-phosphate dehydrogenase, active site
 IPR022674  Glucose-6-phosphate dehydrogenase, NAD-binding
 IPR022675  Glucose-6-phosphate dehydrogenase, C-terminal
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006098 pentose-phosphate shunt IEA
 biological_processGO:0006695 cholesterol biosynthetic process ISO
 biological_processGO:0006739 NADP metabolic process ISS
 biological_processGO:0006740 NADPH regeneration ISO
 biological_processGO:0006741 NADP biosynthetic process IMP
 biological_processGO:0006749 glutathione metabolic process ISO
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0009051 pentose-phosphate shunt, oxidative branch ISO
 biological_processGO:0010734 negative regulation of protein glutathionylation ISO
 biological_processGO:0019322 pentose biosynthetic process ISO
 biological_processGO:0032613 interleukin-10 production IMP
 biological_processGO:0032615 interleukin-12 production IMP
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0043249 erythrocyte maturation ISO
 biological_processGO:0046390 ribose phosphate biosynthetic process ISO
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0051156 glucose 6-phosphate metabolic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISO
 molecular_functionGO:0004345 glucose-6-phosphate dehydrogenase activity IEA
 molecular_functionGO:0005536 glucose binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes
Pentose phosphate pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: G6pdxa-m1Neu/G6pdxa-m1Neu
Genetic Background: involves: 102/El * C3H/El * T-stock

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003891 increased allantois apoptosis "increase in the number of cells of the allantois undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012606 increased glutathione level 
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: G6pdxtm1Luz/G6pdx+
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031400 G6pdx / Q00612 / Glucose-6-phosphate 1-dehydrogenase X / G6PD* / P11413* / glucose-6-phosphate dehydrogenase*  / complex
 ENSMUSG00000089992 G6pd2 / G6PD* / P11413* / glucose-6-phosphate dehydrogenase*  / complex






 

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