ENSMUSG00000029094


Mus musculus

Features
Gene ID: ENSMUSG00000029094
  
Biological name :Afap1
  
Synonyms : Actin filament-associated protein 1 / Afap1 / Q80YS6
  
Possible biological names infered from orthology : Q8N556
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B3
Gene start: 35893319
Gene end: 36003923
  
Corresponding Affymetrix probe sets: 10521440 (MoGene1.0st)   1436729_at (Mouse Genome 430 2.0 Array)   1442788_at (Mouse Genome 430 2.0 Array)   1456361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119364
Ensembl peptide - ENSMUSP00000148414
Ensembl peptide - ENSMUSP00000067779
NCBI entrez gene - 70292     See in Manteia.
MGI - MGI:1917542
RefSeq - XM_006504098
RefSeq - XM_006504100
RefSeq - NM_027373
RefSeq Peptide - NP_081649
swissprot - Q80YS6
swissprot - E9Q8X9
swissprot - A0A1D5RLL0
Ensembl - ENSMUSG00000029094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 afap1ENSDARG00000055284Danio rerio
 AFAP1ENSGALG00000015556Gallus gallus
 AFAP1ENSG00000196526Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BZI0 / Afap1l1 / Actin filament-associated protein 1-like 1 / Q8TED9*ENSMUSG0000003303245
Q5DTU0 / Afap1l2 / Actin filament-associated protein 1-like 2 / Q8N4X5*ENSMUSG0000002508336


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029907  Actin filament-associated protein 1
 IPR030113  Actin-filament associated protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esrp1tm1.2Rpc/Esrp1tm1.2Rpc,Esrp2tm1(KOMP)Vlcg/Esrp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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