ENSMUSG00000025083


Mus musculus

Features
Gene ID: ENSMUSG00000025083
  
Biological name :Afap1l2
  
Synonyms : Actin filament-associated protein 1-like 2 / Afap1l2 / Q5DTU0
  
Possible biological names infered from orthology : Q8N4X5
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: D2
Gene start: 56912361
Gene end: 57008228
  
Corresponding Affymetrix probe sets: 10468668 (MoGene1.0st)   1436870_s_at (Mouse Genome 430 2.0 Array)   1455833_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113745
Ensembl peptide - ENSMUSP00000112387
Ensembl peptide - ENSMUSP00000120490
Ensembl peptide - ENSMUSP00000153082
Ensembl peptide - ENSMUSP00000123400
Ensembl peptide - ENSMUSP00000107210
NCBI entrez gene - 226250     See in Manteia.
MGI - MGI:2147658
RefSeq - XM_017318171
RefSeq - NM_001177796
RefSeq - NM_001177797
RefSeq - NM_146102
RefSeq - XM_006527024
RefSeq - XM_017318168
RefSeq - XM_017318169
RefSeq - XM_017318170
RefSeq Peptide - NP_001171267
RefSeq Peptide - NP_666214
RefSeq Peptide - NP_001171268
swissprot - A0A286YCN9
swissprot - A0A0R4J1L6
swissprot - Q5DTU0
swissprot - D3YZD3
swissprot - D3YYQ6
Ensembl - ENSMUSG00000025083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 afap1l2ENSDARG00000074806Danio rerio
 AFAP1L2ENSGALG00000008999Gallus gallus
 Q8N4X5ENSG00000169129Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Afap1 / Q80YS6 / Actin filament-associated protein 1 / Q8N556*ENSMUSG0000002909431
Q8BZI0 / Afap1l1 / Actin filament-associated protein 1-like 1 / Q8TED9*ENSMUSG0000003303231


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR030113  Actin-filament associated protein
 IPR030115  Actin filament-associated protein 1-like 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0032675 regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0042169 SH2 domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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