ENSMUSG00000029110


Mus musculus

Features
Gene ID: ENSMUSG00000029110
  
Biological name :Rnf4
  
Synonyms : E3 ubiquitin-protein ligase RNF4 / Q9QZS2 / Rnf4
  
Possible biological names infered from orthology : P78317 / ring finger protein 4
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 34336289
Gene end: 34355629
  
Corresponding Affymetrix probe sets: 10521174 (MoGene1.0st)   1423654_a_at (Mouse Genome 430 2.0 Array)   1451072_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030992
Ensembl peptide - ENSMUSP00000138411
Ensembl peptide - ENSMUSP00000138555
Ensembl peptide - ENSMUSP00000138594
NCBI entrez gene - 19822     See in Manteia.
MGI - MGI:1201691
RefSeq - NM_001304270
RefSeq - NM_001304269
RefSeq - NM_011278
RefSeq Peptide - NP_001291198
RefSeq Peptide - NP_001291199
RefSeq Peptide - NP_035408
swissprot - Q9QZS2
swissprot - S4R2C9
Ensembl - ENSMUSG00000029110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf4ENSDARG00000090993Danio rerio
 RNF4ENSGALG00000015668Gallus gallus
 RNF4ENSG00000063978Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016567 protein ubiquitination IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046685 response to arsenic-containing substance ISO
 biological_processGO:0051865 protein autoubiquitination ISS
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:0070979 protein K11-linked ubiquitination ISS
 biological_processGO:0085020 protein K6-linked ubiquitination ISS
 biological_processGO:0090169 regulation of spindle assembly ISO
 biological_processGO:0090234 regulation of kinetochore assembly ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016605 PML body IBA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031491 nucleosome binding ISS
 molecular_functionGO:0032184 SUMO polymer binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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