ENSG00000063978


Homo sapiens

Features
Gene ID: ENSG00000063978
  
Biological name :RNF4
  
Synonyms : P78317 / ring finger protein 4 / RNF4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 2462220
Gene end: 2625320
  
Corresponding Affymetrix probe sets: 212696_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423100
Ensembl peptide - ENSP00000423186
Ensembl peptide - ENSP00000446369
Ensembl peptide - ENSP00000427212
Ensembl peptide - ENSP00000426615
Ensembl peptide - ENSP00000426503
Ensembl peptide - ENSP00000425724
Ensembl peptide - ENSP00000425667
Ensembl peptide - ENSP00000424076
Ensembl peptide - ENSP00000315212
Ensembl peptide - ENSP00000422500
Ensembl peptide - ENSP00000422619
Ensembl peptide - ENSP00000422728
Ensembl peptide - ENSP00000422938
NCBI entrez gene - 6047     See in Manteia.
OMIM - 602850
RefSeq - NM_001185010
RefSeq - NM_002938
RefSeq - NM_001185009
RefSeq Peptide - NP_001171938
RefSeq Peptide - NP_001171939
RefSeq Peptide - NP_002929
swissprot - D6R9E0
swissprot - H0YAI5
swissprot - D6RJF5
swissprot - P78317
swissprot - D6RJ08
swissprot - D6RBZ1
swissprot - D6RBQ7
swissprot - D6RAD8
swissprot - D6RA71
Ensembl - ENSG00000063978
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf4ENSDARG00000090993Danio rerio
 RNF4ENSGALG00000015668Gallus gallus
 Rnf4ENSMUSG00000029110Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016567 protein ubiquitination IBA
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046685 response to arsenic-containing substance IDA
 biological_processGO:0051865 protein autoubiquitination ISS
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:0070979 protein K11-linked ubiquitination ISS
 biological_processGO:0085020 protein K6-linked ubiquitination ISS
 biological_processGO:0090169 regulation of spindle assembly IMP
 biological_processGO:0090234 regulation of kinetochore assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031491 nucleosome binding ISS
 molecular_functionGO:0032184 SUMO polymer binding ISS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding NAS
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000063978 RNF4 / P78317 / ring finger protein 4  / complex






 

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