ENSMUSG00000029156


Mus musculus

Features
Gene ID: ENSMUSG00000029156
  
Biological name :Sgcb
  
Synonyms : Beta-sarcoglycan / P82349 / Sgcb
  
Possible biological names infered from orthology : Q16585 / sarcoglycan beta
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.3
Gene start: 73632749
Gene end: 73647790
  
Corresponding Affymetrix probe sets: 10530633 (MoGene1.0st)   1419667_at (Mouse Genome 430 2.0 Array)   1419668_at (Mouse Genome 430 2.0 Array)   1436678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079937
NCBI entrez gene - 24051     See in Manteia.
MGI - MGI:1346523
RefSeq - NM_011890
RefSeq Peptide - NP_036020
swissprot - P82349
Ensembl - ENSMUSG00000029156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgcbENSDARG00000052341Danio rerio
 SGCBENSGALG00000013968Gallus gallus
 SGCBENSG00000163069Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006875  Sarcoglycan complex subunit protein
 IPR027659  Beta-sarcoglycan


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0048747 muscle fiber development IMP
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0097084 vascular smooth muscle cell development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016010 dystrophin-associated glycoprotein complex IEA
 cellular_componentGO:0016011 dystroglycan complex IDA
 cellular_componentGO:0016012 sarcoglycan complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otcspf
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otcspf
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Acadsdel-J/Acadsdel-J,Otcspf/Otcspf
Genetic Background: involves: BALB/cByJ * CD-1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003199 muscle calcification "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0005412 vascular stenosis "narrowing or constriction of a blood vessel" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
Show

Allelic Composition: Nle1tm1Cba/Nle1tm1Cba
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL/J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009421 increased gastrocnemius weight "increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009427 increased tibialis anterior weight "increase in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcbtm1Oza/Sgcbtm1Oza
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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