ENSMUSG00000029233


Mus musculus

Features
Gene ID: ENSMUSG00000029233
  
Biological name :Srd5a3
  
Synonyms : Q9WUP4 / Srd5a3 / steroid 5 alpha-reductase 3
  
Possible biological names infered from orthology : Q9H8P0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.3
Gene start: 76140271
Gene end: 76155504
  
Corresponding Affymetrix probe sets: 10522589 (MoGene1.0st)   1423573_at (Mouse Genome 430 2.0 Array)   1423574_s_at (Mouse Genome 430 2.0 Array)   1439241_x_at (Mouse Genome 430 2.0 Array)   1445180_at (Mouse Genome 430 2.0 Array)   1456691_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109134
Ensembl peptide - ENSMUSP00000115297
Ensembl peptide - ENSMUSP00000116801
Ensembl peptide - ENSMUSP00000031143
Ensembl peptide - ENSMUSP00000109135
NCBI entrez gene - 57357     See in Manteia.
MGI - MGI:1930252
RefSeq - XM_006535162
RefSeq - NM_020611
RefSeq Peptide - NP_065636
swissprot - F6WPW1
swissprot - A0A1C7ZMY6
swissprot - Q9WUP4
swissprot - H9KV08
Ensembl - ENSMUSG00000029233
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5RIU9ENSDARG00000043307Danio rerio
 SRD5A3ENSGALG00000013804Gallus gallus
 Q9H8P0ENSG00000128039Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001104  3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006488 dolichol-linked oligosaccharide biosynthetic process IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016095 polyprenol catabolic process IMP
 biological_processGO:0019348 dolichol metabolic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA
 molecular_functionGO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0047751 cholestenone 5-alpha-reductase activity IEA
 molecular_functionGO:0102389 polyprenol reductase activity IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Synthesis of Dolichyl-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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