ENSMUSG00000029291


Mus musculus

Features
Gene ID: ENSMUSG00000029291
  
Biological name :Rufy3
  
Synonyms : Protein RUFY3 / Q9D394 / Rufy3
  
Possible biological names infered from orthology : Q7L099 / RUN and FYVE domain containing 3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 88565040
Gene end: 88651392
  
Corresponding Affymetrix probe sets: 10522976 (MoGene1.0st)   1424402_at (Mouse Genome 430 2.0 Array)   1424403_a_at (Mouse Genome 430 2.0 Array)   1442786_s_at (Mouse Genome 430 2.0 Array)   1455027_at (Mouse Genome 430 2.0 Array)   1455605_at (Mouse Genome 430 2.0 Array)   1459309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143115
Ensembl peptide - ENSMUSP00000143302
Ensembl peptide - ENSMUSP00000143770
Ensembl peptide - ENSMUSP00000031229
Ensembl peptide - ENSMUSP00000143209
NCBI entrez gene - 52822     See in Manteia.
MGI - MGI:106484
RefSeq - XM_017320984
RefSeq - NM_001289774
RefSeq - NM_001289775
RefSeq - NM_001289776
RefSeq - NM_001289777
RefSeq - NM_027530
RefSeq - XM_006535109
RefSeq - XM_006535111
RefSeq - XM_006535112
RefSeq - XM_006535113
RefSeq - XM_006535114
RefSeq - XM_006535115
RefSeq - XM_006535116
RefSeq - XM_017320983
RefSeq Peptide - NP_001276703
RefSeq Peptide - NP_001276704
RefSeq Peptide - NP_001276705
RefSeq Peptide - NP_001276706
RefSeq Peptide - NP_001346137
RefSeq Peptide - NP_081806
swissprot - Q9D394
swissprot - A0A0G2JFT8
Ensembl - ENSMUSG00000029291
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rufy3ENSDARG00000029692Danio rerio
 RUFY3ENSGALG00000011564Gallus gallus
 RUFY3ENSG00000018189Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rufy1 / Q8BIJ7 / RUN and FYVE domain-containing protein 1 / Q96T51* / RUN and FYVE domain containing 1*ENSMUSG0000002037547
Rufy2 / Q8R4C2 / RUN and FYVE domain-containing 2 / Q8WXA3*ENSMUSG0000002007047
Q6PDC0 / Rundc3b / RUN domain containing 3B / Q96NL0*ENSMUSG0000004057017
O08576 / Rundc3a / RUN domain-containing protein 3A / Q59EK9* / RUN domain containing 3A*ENSMUSG0000000657516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR004012  RUN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR037213  RUN domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0045773 positive regulation of axon extension IDA
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0050771 negative regulation of axonogenesis ISS
 biological_processGO:0050772 positive regulation of axonogenesis IDA
 biological_processGO:0090316 positive regulation of intracellular protein transport IDA
 biological_processGO:2000114 regulation of establishment of cell polarity IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0071437 invadopodium ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0020581 abnormal neuron polarity "any anomaly in the normal orientation or arrangement of the axon(s) and dendrite(s) in relation to the neuronal cell body" [MGI:smb, PMID:26133936]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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