ENSMUSG00000029314


Mus musculus

Features
Gene ID: ENSMUSG00000029314
  
Biological name :Gpat3
  
Synonyms : glycerol-3-phosphate acyltransferase 3 / Gpat3 / Q8C0N2
  
Possible biological names infered from orthology : Q53EU6
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E4
Gene start: 100845713
Gene end: 100899102
  
Corresponding Affymetrix probe sets: 10523547 (MoGene1.0st)   1454799_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124076
Ensembl peptide - ENSMUSP00000031255
Ensembl peptide - ENSMUSP00000090667
Ensembl peptide - ENSMUSP00000108508
Ensembl peptide - ENSMUSP00000114813
NCBI entrez gene - 231510     See in Manteia.
MGI - MGI:3603816
RefSeq - XM_011249432
RefSeq - XM_011249433
RefSeq - NM_172715
RefSeq - XM_011249431
RefSeq Peptide - NP_766303
swissprot - Q8C0N2
swissprot - D3YUY8
Ensembl - ENSMUSG00000029314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3KGT9ENSDARG00000006491Danio rerio
 gpat3ENSDARG00000016048Danio rerio
 ENSGALG00000043256Gallus gallus
 GPAT3ENSGALG00000011221Gallus gallus
 GPAT3ENSG00000138678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpat4 / Q8K2C8 / glycerol-3-phosphate acyltransferase 4 / Q86UL3*ENSMUSG0000003154566


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process ISO
 biological_processGO:0032006 regulation of TOR signaling ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
 molecular_functionGO:0004366 glycerol-3-phosphate O-acyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0102420 sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm1(tetO-U2AF1*S34F)Mjwa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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