ENSMUSG00000031545


Mus musculus

Features
Gene ID: ENSMUSG00000031545
  
Biological name :Gpat4
  
Synonyms : glycerol-3-phosphate acyltransferase 4 / Gpat4 / Q8K2C8
  
Possible biological names infered from orthology : Q86UL3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 23171265
Gene end: 23208346
  
Corresponding Affymetrix probe sets: 10577604 (MoGene1.0st)   1422841_at (Mouse Genome 430 2.0 Array)   1436276_at (Mouse Genome 430 2.0 Array)   1450776_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147679
Ensembl peptide - ENSMUSP00000127325
NCBI entrez gene - 102247     See in Manteia.
MGI - MGI:2142716
RefSeq - NM_018743
RefSeq - XM_011242104
RefSeq Peptide - NP_061213
swissprot - A0A1B0GRV5
swissprot - Q8K2C8
Ensembl - ENSMUSG00000031545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpat4ENSDARG00000019897Danio rerio
 GPAT4ENSGALG00000003518Gallus gallus
 GPAT4ENSG00000158669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpat3 / Q8C0N2 / glycerol-3-phosphate acyltransferase 3 / Q53EU6*ENSMUSG0000002931464


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002071 glandular epithelial cell maturation IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0006637 acyl-CoA metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process IMP
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process IMP
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0046339 diacylglycerol metabolic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane NAS
 molecular_functionGO:0004366 glycerol-3-phosphate O-acyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0102420 sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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