ENSMUSG00000029416


Mus musculus

Features
Gene ID: ENSMUSG00000029416
  
Biological name :Slc15a4
  
Synonyms : Q91W98 / Slc15a4 / Solute carrier family 15 member 4
  
Possible biological names infered from orthology : Q8N697
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G1.2
Gene start: 127595664
Gene end: 127632897
  
Corresponding Affymetrix probe sets: 10533993 (MoGene1.0st)   1441925_at (Mouse Genome 430 2.0 Array)   1448385_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116529
Ensembl peptide - ENSMUSP00000142476
Ensembl peptide - ENSMUSP00000123116
Ensembl peptide - ENSMUSP00000121595
Ensembl peptide - ENSMUSP00000117258
Ensembl peptide - ENSMUSP00000031367
Ensembl peptide - ENSMUSP00000116420
NCBI entrez gene - 100561     See in Manteia.
MGI - MGI:2140796
RefSeq - XM_006504272
RefSeq - NM_133895
RefSeq - XM_006504271
RefSeq Peptide - NP_598656
swissprot - F7AZ26
swissprot - D3Z5E9
swissprot - D6RDC2
swissprot - Q91W98
swissprot - D3Z4X0
swissprot - F6QFB4
swissprot - A0A0G2JDS1
Ensembl - ENSMUSG00000029416
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc15a4ENSDARG00000102612Danio rerio
 SLC15A4ENSGALG00000002695Gallus gallus
 Q8N697ENSG00000139370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BPX9 / Slc15a3 / Solute carrier family 15 member 3 / Q8IY34*ENSMUSG0000002473749
Slc15a2 / solute carrier family 15 (H+/peptide transporter), member 2 / Q16348* / solute carrier family 15 member 2*ENSMUSG0000002289922
Q9JIP7 / Slc15a1 / solute carrier family 15 (oligopeptide transporter), member 1 / P46059* / solute carrier family 15 member 1*ENSMUSG0000002555721
Q8CBB2 / Slc15a5 / Solute carrier family 15 member 5 / A6NIM6*ENSMUSG0000004437821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000109  Proton-dependent oligopeptide transporter family
 IPR018456  PTR2 family proton/oligopeptide symporter, conserved site
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006857 oligopeptide transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0015833 peptide transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Proton/oligopeptide cotransporters
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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