ENSMUSG00000029445


Mus musculus

Features
Gene ID: ENSMUSG00000029445
  
Biological name :Hpd
  
Synonyms : 4-hydroxyphenylpyruvate dioxygenase / Hpd / P49429
  
Possible biological names infered from orthology : P32754
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 123171807
Gene end: 123182727
  
Corresponding Affymetrix probe sets: 10533612 (MoGene1.0st)   1424618_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118702
Ensembl peptide - ENSMUSP00000121922
Ensembl peptide - ENSMUSP00000031398
NCBI entrez gene - 15445     See in Manteia.
MGI - MGI:96213
RefSeq - NM_008277
RefSeq Peptide - NP_032303
swissprot - P49429
swissprot - D3Z1U3
swissprot - F6X9Z6
Ensembl - ENSMUSG00000029445
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpdbENSDARG00000044935Danio rerio
 HPDENSGALG00000004343Gallus gallus
 HPDENSG00000158104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hpdl / Q8K248 / 4-hydroxyphenylpyruvate dioxygenase-like protein / Q96IR7* / 4-hydroxyphenylpyruvate dioxygenase like*ENSMUSG0000004315524


Protein motifs (from Interpro)
Interpro ID Name
 IPR004360  Glyoxalase/fosfomycin resistance/dioxygenase domain
 IPR005956  4-hydroxyphenylpyruvate dioxygenase
 IPR029068  Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
 IPR037523  Vicinal oxygen chelate (VOC) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006559 L-phenylalanine catabolic process IEA
 biological_processGO:0006572 tyrosine catabolic process IBA
 biological_processGO:0009072 aromatic amino acid family metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003868 4-hydroxyphenylpyruvate dioxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Phenylalanine and tyrosine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzd9tm1Sjp/Fzd9+
Genetic Background: involves: C57BL/6J

 MP:0013724 decreased circulating tyrosine level "the amount of the amino acid histidine in the blood is less than expected" [MGI:csmith]
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Allelic Composition: Fzd9tm1Sjp/Fzd9+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029445 Hpd / P49429 / 4-hydroxyphenylpyruvate dioxygenase / P32754*  / complex






 

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