ENSMUSG00000029465


Mus musculus

Features
Gene ID: ENSMUSG00000029465
  
Biological name :Arpc3
  
Synonyms : Actin-related protein 2/3 complex subunit 3 / Arpc3 / Q9JM76
  
Possible biological names infered from orthology : O15145
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 122391878
Gene end: 122414184
  
Corresponding Affymetrix probe sets: 10525397 (MoGene1.0st)   1448279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099584
Ensembl peptide - ENSMUSP00000143210
Ensembl peptide - ENSMUSP00000107345
Ensembl peptide - ENSMUSP00000107342
Ensembl peptide - ENSMUSP00000031421
NCBI entrez gene - 56378     See in Manteia.
MGI - MGI:1928375
RefSeq - NM_019824
RefSeq Peptide - NP_062798
swissprot - H7BWZ3
swissprot - D3Z2F8
swissprot - Q9JM76
swissprot - D3Z2F7
swissprot - A0A0G2JFK7
Ensembl - ENSMUSG00000029465
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arpc3ENSDARG00000057882Danio rerio
 ARPC3ENSGALG00000003820Gallus gallus
 ARPC3ENSG00000111229Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007204  Actin-related protein 2/3 complex subunit 3
 IPR036753  Actin-related protein 2/3 complex subunit 3 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005885 Arp2/3 protein complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0061850 growth cone leading edge IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm3(APOE_i4)Yhg,Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0002800 abnormal short-term recognition memory "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

Allelic Composition: Arpc3Tn(sb-lacZ,GFP)T5.117Jtak/Arpc3tm1Jtak
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Arpc3tm1Ssod/Arpc3tm1Ssod,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: BALB/c * C57BL

Allelic Composition: Arpc3tm1Ssod/Arpc3tm1Ssod,Gt(ROSA)26Sortm2(CAG-tdTomato)Fawa/Gt(ROSA)26Sor+,Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

Allelic Composition: Arpc3Tn(sb-lacZ,GFP)T5.117Jtak/Arpc3tm1Jtak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020414 abnormal fibroblast physiology "any functional anomaly in the cellular physiological processes carried out by a fibroblast cell population" [mgi:anna]
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020415 abnormal fibroblast chemotaxis "any anomaly in the directed movement of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna]
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Allelic Composition: Arpc3Gt(XG476)Byg/Arpc3Gt(XG476)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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