ENSMUSG00000029571


Mus musculus

Features
Gene ID: ENSMUSG00000029571
  
Biological name :Tmem106b
  
Synonyms : Q80X71 / Tmem106b / transmembrane protein 106B
  
Possible biological names infered from orthology : Q9NUM4
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A1
Gene start: 13069759
Gene end: 13089269
  
Corresponding Affymetrix probe sets: 10536429 (MoGene1.0st)   1430592_at (Mouse Genome 430 2.0 Array)   1435074_at (Mouse Genome 430 2.0 Array)   1435075_at (Mouse Genome 430 2.0 Array)   1452290_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031556
Ensembl peptide - ENSMUSP00000123208
Ensembl peptide - ENSMUSP00000122392
Ensembl peptide - ENSMUSP00000122107
NCBI entrez gene - 71900     See in Manteia.
MGI - MGI:1919150
RefSeq - XM_006505169
RefSeq - NM_027992
RefSeq Peptide - NP_082268
swissprot - D3Z191
swissprot - D3Z6E0
swissprot - Q80X71
swissprot - D3Z0M2
Ensembl - ENSMUSG00000029571
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem106bbENSDARG00000035949Danio rerio
 TMEM106BENSGALG00000035140Gallus gallus
 Q9NUM4ENSG00000106460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80VP8 / Tmem106c / Mus musculus transmembrane protein 106C (Tmem106c), transcript variant 3, mRNA. / Q9BVX2* / transmembrane protein 106C*ENSMUSG0000005236942
Q8VC04 / Tmem106a / Mus musculus transmembrane protein 106A (Tmem106a), transcript variant 2, mRNA. / Q96A25* / transmembrane protein 106A*ENSMUSG0000003494737


Protein motifs (from Interpro)
Interpro ID Name
 IPR009790  Protein of unknown function DUF1356, TMEM106
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0007041 lysosomal transport IMP
 biological_processGO:0032418 lysosome localization IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:1900006 positive regulation of dendrite development IMP
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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