ENSMUSG00000029591


Mus musculus

Features
Gene ID: ENSMUSG00000029591
  
Biological name :Ung
  
Synonyms : P97931 / Ung / uracil DNA glycosylase
  
Possible biological names infered from orthology : P13051
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 114130386
Gene end: 114139323
  
Corresponding Affymetrix probe sets: 10524450 (MoGene1.0st)   1425753_a_at (Mouse Genome 430 2.0 Array)   1457922_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099644
Ensembl peptide - ENSMUSP00000142484
Ensembl peptide - ENSMUSP00000114140
Ensembl peptide - ENSMUSP00000107894
Ensembl peptide - ENSMUSP00000031587
NCBI entrez gene - 22256     See in Manteia.
MGI - MGI:109352
RefSeq - XM_006530284
RefSeq - NM_001040691
RefSeq - NM_011677
RefSeq Peptide - NP_035807
RefSeq Peptide - NP_001035781
swissprot - D3YW18
swissprot - Q791V7
swissprot - P97931
swissprot - A0A0G2JDS8
swissprot - D3Z1G1
Ensembl - ENSMUSG00000029591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ungaENSDARG00000042527Danio rerio
 UNGENSGALG00000021285Gallus gallus
 UNGENSG00000076248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002043  Uracil-DNA glycosylase family 1
 IPR005122  Uracil-DNA glycosylase-like
 IPR018085  Uracil-DNA glycosylase, active site
 IPR036895  Uracil-DNA glycosylase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016446 somatic hypermutation of immunoglobulin genes IMP
 biological_processGO:0016447 somatic recombination of immunoglobulin gene segments IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045830 positive regulation of isotype switching IGI
 biological_processGO:0097510 base-excision repair, AP site formation via deaminated base removal ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0003684 damaged DNA binding ISO
 molecular_functionGO:0004844 uracil DNA N-glycosylase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA
 molecular_functionGO:0043024 ribosomal small subunit binding ISO


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa6tm1Hhs/Ncoa6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncoa6tm1Hhs/Ncoa6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd

 MP:0009796 abnormal base-excision repair "any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]
Show

Allelic Composition: Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0009797 abnormal mismatch repair "any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination" [GO:0006298]
Show

Allelic Composition: Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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