ENSMUSG00000029673


Mus musculus

Features
Gene ID: ENSMUSG00000029673
  
Biological name :Auts2
  
Synonyms : A0A087WPF7 / Autism susceptibility 2 protein homolog / Auts2
  
Possible biological names infered from orthology : AUTS2, activator of transcription and developmental regulator / Q8WXX7
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 131437333
Gene end: 132543344
  
Corresponding Affymetrix probe sets: 10534168 (MoGene1.0st)   1427293_a_at (Mouse Genome 430 2.0 Array)   1438680_at (Mouse Genome 430 2.0 Array)   1443062_at (Mouse Genome 430 2.0 Array)   1452379_at (Mouse Genome 430 2.0 Array)   1457139_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124730
Ensembl peptide - ENSMUSP00000141082
Ensembl peptide - ENSMUSP00000139759
Ensembl peptide - ENSMUSP00000138441
Ensembl peptide - ENSMUSP00000136954
Ensembl peptide - ENSMUSP00000125706
Ensembl peptide - ENSMUSP00000124027
NCBI entrez gene - 319974     See in Manteia.
MGI - MGI:1919847
RefSeq - NM_177047
RefSeq Peptide - NP_796021
swissprot - A0A087WSK2
swissprot - A0A087WPF7
swissprot - J3QNT9
swissprot - E9PZ86
swissprot - S4R200
swissprot - E0CZ47
swissprot - A0A2C9F2I4
Ensembl - ENSMUSG00000029673
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 auts2aENSDARG00000056427Danio rerio
 auts2bENSDARG00000020946Danio rerio
 AUTS2ENSGALG00000001153Gallus gallus
 AUTS2ENSG00000158321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbrsl1 / fibrosin-1-like protein isoform 3 / Q9HCM7* / fibrosin like 1*ENSMUSG0000004332331
Fbrs / Q8R089 / Probable fibrosin-1 / Q9HAH7* / fibrosin*ENSMUSG0000004242319


Protein motifs (from Interpro)
Interpro ID Name
 IPR023246  Autism susceptibility gene 2 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010592 positive regulation of lamellipodium assembly IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0035022 positive regulation of Rac protein signal transduction IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IEA
 biological_processGO:0060013 righting reflex IMP
 biological_processGO:0097484 dendrite extension IMP
 biological_processGO:0098582 innate vocalization behavior IMP
 biological_processGO:2000620 positive regulation of histone H4-K16 acetylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

Allelic Composition: Auts2tm1.1Dare/Auts2+,Tg(Nes-cre)1Kln/0
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Auts2tm1.2Mhos/Auts2tm1.2Mhos
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Auts2tm1.1Mhos/Auts2tm1.1Mhos
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005356 positive geotaxis "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

Allelic Composition: Auts2tm1Mhos/Auts2+
Genetic Background: C57BL/6N-Auts2tm1Mhos

Allelic Composition: Auts2tm1.2Mhos/Auts2tm1.2Mhos
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Auts2tm1.2Mhos/Auts2+
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Auts2tm1.1Mhos/Auts2tm1.1Mhos
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Auts2tm1Mhos/Auts2+
Genetic Background: C57BL/6N-Auts2tm1Mhos

 MP:0010726 abnormal collateral sprouting "aberrant response of a neuron to form new neuritic processes (sprouts) that emerge from the nerve fibers or terminal arborizations in response to nerve injury (such as section or denervation), application of neurotoxin, or target tissue atrophy (usually due to disease)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Auts2tm1.2Mhos/Auts2tm1.2Mhos
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Auts2tm1.2Mhos/Auts2+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Marveld2tm1Sats/Marveld2tm1Sats
Genetic Background: B6.Cg-Marveld2tm1Sats

Allelic Composition: Auts2tm1.2Mhos/Auts2tm1.2Mhos
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
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Allelic Composition: Auts2tm1Mhos/Auts2+
Genetic Background: C57BL/6N-Auts2tm1Mhos

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Elfn1tm1.1Jaru/Elfn1tm1.1Jaru
Genetic Background: involves: C57BL/6

Allelic Composition: Auts2tm1.1Dare/Auts2+,Tg(Nes-cre)1Kln/0
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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