ENSMUSG00000029752


Mus musculus

Features
Gene ID: ENSMUSG00000029752
  
Biological name :Asns
  
Synonyms : Asns / Asparagine synthetase [glutamine-hydrolyzing] / Q61024
  
Possible biological names infered from orthology : P08243
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 7675169
Gene end: 7693254
  
Corresponding Affymetrix probe sets: 10543067 (MoGene1.0st)   1433966_x_at (Mouse Genome 430 2.0 Array)   1451095_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111204
Ensembl peptide - ENSMUSP00000120489
Ensembl peptide - ENSMUSP00000118003
Ensembl peptide - ENSMUSP00000115415
Ensembl peptide - ENSMUSP00000031766
NCBI entrez gene - 27053     See in Manteia.
MGI - MGI:1350929
RefSeq - XM_006505093
RefSeq - NM_012055
RefSeq - XM_006505092
RefSeq Peptide - NP_036185
swissprot - D3Z0C2
swissprot - Q61024
swissprot - D3YYR0
swissprot - D3Z028
Ensembl - ENSMUSG00000029752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asnsENSDARG00000016375Danio rerio
 ASNSENSGALG00000009748Gallus gallus
 ASNSENSG00000070669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001962  Asparagine synthase
 IPR006426  Asparagine synthase, glutamine-hydrolyzing
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR017932  Glutamine amidotransferase type 2 domain
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR033738  Asparagine synthase, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006529 asparagine biosynthetic process IBA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0031427 response to methotrexate IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032354 response to follicle-stimulating hormone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0042149 cellular response to glucose starvation ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISO
 biological_processGO:0070981 L-asparagine biosynthetic process IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004066 asparagine synthase (glutamine-hydrolyzing) activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0048037 cofactor binding IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002800 abnormal short-term recognition memory "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

Allelic Composition: Asnstm1a(EUCOMM)Wtsi/Asns+
Genetic Background: C57BL/6N-Asnstm1a(EUCOMM)Wtsi

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

Allelic Composition: Asnstm1a(EUCOMM)Wtsi/Asns+
Genetic Background: C57BL/6N-Asnstm1a(EUCOMM)Wtsi

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kbtbd2em1Btlr/Kbtbd2em1Btlr,Pik3r1em1Btlr/Pik3r1em1Btlr
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029752 Asns / Q61024 / Asparagine synthetase [glutamine-hydrolyzing] / P08243*  / complex






 

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