ENSMUSG00000030001


Mus musculus

Features
Gene ID: ENSMUSG00000030001
  
Biological name :Figla
  
Synonyms : Factor in the germline alpha / Figla / O55208
  
Possible biological names infered from orthology : folliculogenesis specific bHLH transcription factor / Q6QHK4
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 86016171
Gene end: 86020996
  
Corresponding Affymetrix probe sets: 10539665 (MoGene1.0st)   1450369_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032070
NCBI entrez gene - 26910     See in Manteia.
MGI - MGI:1349421
RefSeq - XM_017321595
RefSeq - NM_012013
RefSeq Peptide - NP_036143
swissprot - O55208
swissprot - H6UWL1
Ensembl - ENSMUSG00000030001
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 figlaENSDARG00000087166Danio rerio
 FIGLAENSG00000183733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048477 oogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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