| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Pank1tm1.1Suja/Pank1tm1.1Suja,Pank2tm1.1Suja/Pank2tm1.1Suja
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
|
| MP:0001145 | abnormal male reproductive anatomy | "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Wt1tm2.1Vih/Wt1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
|
| MP:0001146 | abnormal testis morphology | "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Wt1tm2.1Vih/Wt1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/0,Wt1tm1Jae/Wt1tm2Vih
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0001152 | Leydig cell hyperplasia | "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065] |
Show
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0001153 | small seminiferous tubules | "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0001154 | seminiferous tubule degeneration | "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] |
Show
Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
|
| MP:0001155 | arrest of spermatogenesis | "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0001156 | abnormal spermatogenesis | "incomplete maturation or aberrant formation of the male gametes" [J:58959] |
Show
Allelic Composition: Hoxa2tm1Fmr/Hoxa2tm1Fmr
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0001750 | increased circulating follicle stimulating hormone level | "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0001751 | increased circulating luteinizing hormone level | "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
Show
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0001925 | male infertility | "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/0,Wt1tm1Jae/Wt1tm2Vih
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0001930 | abnormal meiosis | "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Hoxa2tm1Fmr/Hoxa2tm1Fmr
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0002212 | abnormal secondary sex determination | "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/0,Wt1tm1Jae/Wt1tm2Vih
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
|
| MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/0,Wt1tm1Jae/Wt1tm2Vih
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002687 | oligozoospermia | "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
Show
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0002776 | Sertoli cell hyperplasia | "increased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002780 | decreased circulating testosterone level | "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002782 | abnormal testicular secretion | "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0002784 | abnormal Sertoli cell morphology | "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
|
| MP:0002786 | abnormal Leydig cell morphology | "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/0,Wt1tm1Jae/Wt1tm2Vih
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
|
| MP:0004109 | abnormal Sertoli cell development | "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/0,Wt1tm1Jae/Wt1tm2Vih
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0004182 | abnormal spermiation | "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Pex5tm1Pec/Pex5tm1Pec,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Tg(Abpa-cre)1Cmal/0,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0004901 | decreased male germ cell number | "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0004929 | decreased epididymis weight | "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
|
| MP:0005159 | azoospermia | "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
|
| MP:0005169 | abnormal male meiosis | "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0005536 | Leydig cell hypoplasia | "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
|
| MP:0006307 | abnormal seminiferous tubule size | "alteration in the diameter of the tubules in the testes where spermatogenesis occurs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0006362 | abnormal male germ cell morphology | "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
|
| MP:0006378 | abnormal spermatogonia morphology | "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
|
| MP:0006379 | abnormal spermatocyte morphology | "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
|
| MP:0006380 | abnormal spermatid morphology | "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Gja1tm1Kwi/Gja1tm1Kwi,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0006428 | ectopic Sertoli cells | "abnormal position of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:71710, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
|
| MP:0008261 | arrest of male meiosis | "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Artm1Chc/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
|
| MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/Plekha5Tg(AMH-cre)1Flor
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
Allelic Composition: Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
|
| MP:0011750 | abnormal seminiferous tubule epithelium morphology | "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith] |
Show
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0013598 | Leydig cell hypertrophy | "increased size of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH)" [MGI:Anna] |
Show
Allelic Composition: Artm1Jdz/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
|
| MP:0013600 | testis degeneration | "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna] |
Show
Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL
Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.1Ipc,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
|
| MP:0020142 | increased anti-sperm antibody level | "elevated level of antibodies to sperm antigens, usually due to compromised Sertoli cell barrier (blood-testis barrier) function; ASAs may be found in the circulation, either free or as immune complexes, in seminal fluid and/or attached to various antigenic sites on the sperm surface (head, midpiece or tail)" [PMID:24803656] |
Show
Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
| MP:0020356 | abnormal Sertoli cell barrier function | "any functional anomaly of the physical barrier found between the blood vessels and the seminiferous tubules of the testes; this barrier between Sertoli cells is composed of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions" [https://en.wikipedia.org/wiki/Blood%E2%80%93testis_barrier, PMID:24713828 http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=4;spage=572;epage=580;aulast=Jiang, PMID:24803656] |
Show
Allelic Composition: Mex3btm1.1Mbld/Mex3btm1.1Mbld,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: C57BL/6 * SJL
|
