ENSMUSG00000030470


Mus musculus

Features
Gene ID: ENSMUSG00000030470
  
Biological name :Csrp3
  
Synonyms : Csrp3 / Cysteine and glycine-rich protein 3 / P50462
  
Possible biological names infered from orthology : P50461
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B4
Gene start: 48830398
Gene end: 48848033
  
Corresponding Affymetrix probe sets: 10563770 (MoGene1.0st)   1460318_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032658
Ensembl peptide - ENSMUSP00000129378
Ensembl peptide - ENSMUSP00000146360
NCBI entrez gene - 13009     See in Manteia.
MGI - MGI:1330824
RefSeq - NM_001198841
RefSeq - NM_013808
RefSeq Peptide - NP_001185770
RefSeq Peptide - NP_038836
swissprot - Q545C7
swissprot - P50462
swissprot - A0A140LHC6
Ensembl - ENSMUSG00000030470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csrp3ENSDARG00000101706Danio rerio
 CSRP3ENSGALG00000004044Gallus gallus
 CSRP3ENSG00000129170Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csrp1 / P97315 / Cysteine and glycine-rich protein 1 / P21291*ENSMUSG0000002642165
Csrp2 / P97314 / Cysteine and glycine-rich protein 2 / Q16527*ENSMUSG0000002018665
Crip2 / Q9DCT8 / Cysteine-rich protein 2 / P52943*ENSMUSG0000000635636
Crip3 / Q6Q6R3 / Cysteine-rich protein 3 / Q6Q6R5*ENSMUSG0000002396831
Crip1 / P63254 / Cysteine-rich protein 1 / P50238*ENSMUSG0000000636016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001781  Zinc finger, LIM-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IGI
 biological_processGO:0003300 cardiac muscle hypertrophy ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0010831 positive regulation of myotube differentiation ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033365 protein localization to organelle IMP
 biological_processGO:0035995 detection of muscle stretch IMP
 biological_processGO:0045662 negative regulation of myoblast differentiation ISO
 biological_processGO:0045663 positive regulation of myoblast differentiation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048738 cardiac muscle tissue development IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0055003 cardiac myofibril assembly IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:1903919 negative regulation of actin filament severing ISO
 biological_processGO:1903920 positive regulation of actin filament severing ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008307 structural constituent of muscle IMP
 molecular_functionGO:0031433 telethonin binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042805 actinin binding IDA
 molecular_functionGO:0043426 MRF binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061629 RNA polymerase II sequence-specific DNA-binding transcription factor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Prkcatm1Jmk/Prkcatm1Jmk
Genetic Background: involves: 129

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Tg(WTbeta2)4Wjk/0
Genetic Background: Not Specified

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Tg(WTbeta2)4Wjk/0
Genetic Background: Not Specified

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: B6.129S7-Mpztm1Msch

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Tg(WTbeta2)4Wjk/0
Genetic Background: Not Specified

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Tg(Myh6-ADRBK1)27Wjk/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Csrp3tm1.1Rkn/Csrp3+
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Csrp3tm1Crni/Csrp3tm1Crni,Tg(Myh6-ADRBK1)27Wjk/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3+
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csrp3tm1.1Rkn/Csrp3tm1.1Rkn
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6N)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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