ENSMUSG00000030545


Mus musculus

Features
Gene ID: ENSMUSG00000030545
  
Biological name :Pex11a
  
Synonyms : Peroxisomal membrane protein 11A / Pex11a / Q9Z211
  
Possible biological names infered from orthology : O75192 / peroxisomal biogenesis factor 11 alpha
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79735957
Gene end: 79743131
  
Corresponding Affymetrix probe sets: 10564805 (MoGene1.0st)   1419365_at (Mouse Genome 430 2.0 Array)   1449442_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032761
NCBI entrez gene - 18631     See in Manteia.
MGI - MGI:1338788
RefSeq - XM_011250824
RefSeq - NM_011068
RefSeq - XM_006540707
RefSeq Peptide - NP_035198
swissprot - Q9Z211
Ensembl - ENSMUSG00000030545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pex11aENSDARG00000060707Danio rerio
 PEX11AENSGALG00000006534Gallus gallus
 O75192ENSG00000166821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pex11b / Q9Z210 / Peroxisomal membrane protein 11B / O96011* / peroxisomal biogenesis factor 11 beta*ENSMUSG0000002810239
Gm42957 / O96011* / PEX11B* / peroxisomal biogenesis factor 11 beta*ENSMUSG0000010644730


Protein motifs (from Interpro)
Interpro ID Name
 IPR008733  Peroxisomal biogenesis factor 11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007031 peroxisome organization ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016557 peroxisome membrane biogenesis IEA
 biological_processGO:0016559 peroxisome fission IBA
 biological_processGO:0044375 regulation of peroxisome size IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005778 peroxisomal membrane IBA
 cellular_componentGO:0005779 integral component of peroxisomal membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrna5tm1Mdb/Chrna5tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: B6.129-Chrnb4tm1Mdb Chrna5tm1Mdb

Allelic Composition: Pex11atm1Sjg/Pex11atm1Sjg,Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrna5tm1Mdb/Chrna5tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: B6.129-Chrnb4tm1Mdb Chrna5tm1Mdb

Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11atm1Sjg/Pex11atm1Sjg,Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11atm1Sjg/Pex11atm1Sjg,Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11atm1Sjg/Pex11atm1Sjg,Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pex11atm1Sjg/Pex11atm1Sjg,Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

 MP:0011969 abnormal circulating triglyceride level "abnormal concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver" [MGI:csmith]
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Allelic Composition: Pex11atm1Itl/Pex11atm1Itl
Genetic Background: C57BL/6-Pex11atm1Itl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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