ENSMUSG00000030591


Mus musculus

Features
Gene ID: ENSMUSG00000030591
  
Biological name :Psmd8
  
Synonyms : proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 / Psmd8 / Q9CX56
  
Possible biological names infered from orthology : P48556 / proteasome 26S subunit, non-ATPase 8
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 29174188
Gene end: 29180701
  
Corresponding Affymetrix probe sets: 10561679 (MoGene1.0st)   1423296_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051657
Ensembl peptide - ENSMUSP00000138613
Ensembl peptide - ENSMUSP00000139514
Ensembl peptide - ENSMUSP00000146882
NCBI entrez gene - 57296     See in Manteia.
MGI - MGI:1888669
RefSeq - NM_026545
RefSeq Peptide - NP_080821
swissprot - Q3TG45
swissprot - Q9CPS5
swissprot - Q9CX56
Ensembl - ENSMUSG00000030591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd8ENSDARG00000020454Danio rerio
 PSMD8ENSG00000099341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006746  26S proteasome non-ATPase regulatory subunit Rpn12
 IPR033464  CSN8/PSMD8/EIF3K
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043248 proteasome assembly IBA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005838 proteasome regulatory particle IEA
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IBA
 cellular_componentGO:0022624 proteasome accessory complex IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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