ENSMUSG00000030760


Mus musculus

Features
Gene ID: ENSMUSG00000030760
  
Biological name :Acer3
  
Synonyms : Acer3 / alkaline ceramidase 3 / Q9D099
  
Possible biological names infered from orthology : Q9NUN7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E1
Gene start: 98206389
Gene end: 98321208
  
Corresponding Affymetrix probe sets: 10565712 (MoGene1.0st)   1429520_a_at (Mouse Genome 430 2.0 Array)   1438435_at (Mouse Genome 430 2.0 Array)   1453179_at (Mouse Genome 430 2.0 Array)   1459771_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112884
Ensembl peptide - ENSMUSP00000120334
Ensembl peptide - ENSMUSP00000116127
Ensembl peptide - ENSMUSP00000033020
NCBI entrez gene - 66190     See in Manteia.
MGI - MGI:1913440
RefSeq - NM_025408
RefSeq Peptide - NP_079684
swissprot - D3YTU8
swissprot - F6RA04
swissprot - D6RJ31
swissprot - Q9D099
Ensembl - ENSMUSG00000030760
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acer3ENSDARG00000093366Danio rerio
 ACER3ENSGALG00000000755Gallus gallus
 ACER3ENSG00000078124Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008901  Ceramidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0046512 sphingosine biosynthetic process IEA
 biological_processGO:0071602 phytosphingosine biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
 molecular_functionGO:0070774 phytoceramidase activity IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Foxg1tm1(cre)Skm/Foxg1+,Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic Background: involves: 129

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009823 abnormal sphingomyelin level "deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0012230 abnormal sphingolipid level 
Show

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0020116 increased sphingosine level "increased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid" [GOC:NV, http://en.wikipedia.org/wiki/Sphingosine]
Show

Allelic Composition: Acer1tm1(KOMP)Vlcg/Acer1tm1(KOMP)Vlcg,Acer2em1Mvw/Acer2em1Mvw
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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