Manteia - Molecule gene

ENSMUSG00000030768

Mus musculus

Features

Gene ID:	ENSMUSG00000030768

Biological name :	Disp1

Synonyms :	1 / Disp1 / Q3TDN0

Possible biological names infered from orthology :	dispatched RND transporter family member 1 / Q96F81

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	H5
Gene start:	183086266
Gene end:	183221522

Corresponding Affymetrix probe sets:	10468909 (MoGene1.0st) 10598178 (MoGene1.0st) 1434795_at (Mouse Genome 430 2.0 Array) 1435132_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000003035 Ensembl peptide - ENSMUSP00000126742 Ensembl peptide - ENSMUSP00000141664 Ensembl peptide - ENSMUSP00000141747 NCBI entrez gene - 68897 See in Manteia. MGI - MGI:1916147 RefSeq - XM_006535596 RefSeq - NM_001278218 RefSeq - NM_001278219 RefSeq - NM_001278220 RefSeq - NM_026866 RefSeq Peptide - NP_001265147 RefSeq Peptide - NP_001265148 RefSeq Peptide - NP_001265149 RefSeq Peptide - NP_081142 swissprot - Q3TDN0 swissprot - A0A0A6YWR7 Ensembl - ENSMUSG00000030768

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
disp1	ENSDARG00000044417	Danio rerio
	ENSGALG00000042048	Gallus gallus
DISP1	ENSG00000154309	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
2 / Disp2 / Q8CIP5 / A7MBM2* / dispatched RND transporter family member 2*	ENSMUSG00000040035	31
Disp3 / dispatched RND transporter family member 3 / Q9P2K9*	ENSMUSG00000041544	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000731	Sterol-sensing domain
IPR003392	Protein patched/dispatched

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007225	patched ligand maturation	IMP
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0009880	embryonic pattern specification	IMP
biological_process	GO:0009953	dorsal/ventral pattern formation	IMP
biological_process	GO:0015833	peptide transport	IMP
biological_process	GO:0060539	diaphragm development	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000090	absent premaxilla	"missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Disp1^tm2Amc/Disp1^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0000106	abnormal basisphenoid bone morphology	"malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Disp1^tm2Amc/Disp1^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Shh^{tm1(EGFP/cre)Cjt}/Shh^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Shh^{tm1(EGFP/cre)Cjt}/Shh^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000292	distended pericardial sacs	"stretched outer parietal layer of the pericardium" [J:25248]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^tm1Amc/Disp1^tm1Amc,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0000550	abnormal forelimb morphology	"malformation of the entire anterior extremities" [MGI:tc]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J
MP:0000565	oligodactyly	"congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Lamp1^tm1Psa/Lamp1^tm1Psa,Lamp2^tm1Psa/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Shh^{tm1(EGFP/cre)Cjt}/Shh^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0000926	absent floor plate	"missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]	Show Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^tm2.1Amc/Disp1^tm2.1Amc,Shh^tm1Amc/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^icb Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001701	incomplete embryo turning	"arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]	Show Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001787	pericardial edema	"accumulation of watery fluid in the pericardial sac of the heart" [J:52597]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm2Amc/Disp1^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shh^{tm1(EGFP/cre)Cjt}/Shh^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab,Shh^tm2Chg/Shh⁺,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster) Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^tm2Amc/Disp1^tm2Amc Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0002243	abnormal vomeronasal organ morphology	"any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002251	abnormal nasopharynx morphology	"structural anomaly of the section of the pharynx that lies above the soft palate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002659	pituitary gland hypoplasia	"decreased size of pituitary gland due to decreased cell number" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002948	abnormal neuronal specification	"defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^tm1Amc,Shh^tm1Amc/Shh⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003425	abnormal optic vesicle formation	"anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003743	abnormal facial morphology	"anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^tm2.1Amc/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^icb Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0004190	abnormal direction of embryo turning	"axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J
MP:0004206	abnormal dermomyotome development	"any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0004251	failure of looping morphogenesis	"failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Disp1^icb/Disp1^tm1Amc,Shh^tm1Amc/Shh⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0004419	absent parietal bone	"absence of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0004440	absent occipital bone	"absence of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0004790	absent upper incisors	"missing the upper pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0004837	abnormal neural fold formation	"any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005157	holoprosencephaly	"presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Disp1^icb/Disp1^tm1Amc,Shh^tm1Amc/Shh⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0005163	cyclopia	"a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]	Show Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0005224	abnormal left-right axis symmetry of the somites	"anomaly in the formation or development of the somites in relation to the left and right sides of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0005269	abnormal occipital bone morphology	"anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005274	abnormal viscerocranium morphology	"anomalous structure or formation of the part of the skull that comprises the facial bones " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005315	absent pituitary gland	"missing gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006029	abnormal sclerotome	"malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0006197	ocular hypotelorism	"the distance between the eyes is reduced" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006290	proboscis	"a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc,Shh^tm1Amc/Shh⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0006306	abnormal nasal pit morphology	"malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm2.1Amc/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0006337	abnormal first branchial arch morphology	"anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008385	absent basisphenoid bone	"absence of the part of the base of the cranium found between the basioccipital and the presphenoid bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0009743	preaxial polydactyly	"duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab,Shh^tm2Chg/Shh⁺,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0009901	abnormal frontonasal prominence morphology	"any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Disp1^icb/Disp1^icb Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm2.1Amc/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^tm2Amc,Shh^{tm1(EGFP/cre)Cjt}/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^tm2.1Amc/Disp1^tm2.1Amc,Shh^tm1Amc/Shh⁺ Genetic Background: involves: 129/Sv * C57BL/6J * SWR
MP:0010335	fused first branchial arch	"the first arch fails to fully divide along the midline" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Disp1^icb/Disp1^icb Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab,Shh^tm2Chg/Shh⁺,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Disp1^icb/Disp1^icb Genetic Background: involves: 129/Sv * C57BL/6J * SWR Allelic Composition: Disp1^icb/Disp1^icb,Ptch1^tm1Mps/Ptch1^tm1Mps Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^tm1Ptch/Disp1^tm1Ptch Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * Swiss Webster)
MP:0011495	abnormal head shape	"any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]	Show Allelic Composition: Adcyap1r1^tm1Bbt/Adcyap1r1^tm1Bbt Genetic Background: involves: 129 * C57BL/6J
MP:0012258	philtrum hypoplasia	"underdevelopment or reduced size of the philtrum, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0013595	absent vomeronasal organ	"lacking the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [MGI:csmith]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0014106	delayed chondrocyte differentiation	"delay in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]	Show Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0030314	absent primary palate	"missing the initial portion of the palate formed from the intermaxillary segment" [MGI:anna, UBERON:0005620]	Show Allelic Composition: Mknk2^tm1Fuku/Mknk2^tm1Fuku Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Disp1^icb/Disp1^tm1Amc Genetic Background: involves: 129X1/SvJ * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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