ENSMUSG00000030894


Mus musculus

Features
Gene ID: ENSMUSG00000030894
  
Biological name :Tpp1
  
Synonyms : O89023 / Tpp1 / Tripeptidyl-peptidase 1
  
Possible biological names infered from orthology : O14773
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 105744811
Gene end: 105752235
  
Corresponding Affymetrix probe sets: 10566529 (MoGene1.0st)   1434768_at (Mouse Genome 430 2.0 Array)   1448313_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147729
Ensembl peptide - ENSMUSP00000033184
NCBI entrez gene - 12751     See in Manteia.
MGI - MGI:1336194
RefSeq - NM_009906
RefSeq - XM_011241668
RefSeq Peptide - NP_034036
swissprot - A0A1B0GRZ6
swissprot - O89023
Ensembl - ENSMUSG00000030894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpp1ENSDARG00000042793Danio rerio
 ENSGALG00000029731Gallus gallus
 ENSGALG00000035308Gallus gallus
 TPP1ENSG00000166340Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015366  Peptidase S53, activation domain
 IPR030400  Sedolisin domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0043171 peptide catabolic process ISS
 biological_processGO:0045453 bone resorption ISS
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0008240 tripeptidyl-peptidase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

Allelic Composition: Tpp1m1J/Tpp1m1J
Genetic Background: STOCK Tpp1m1J/GrsrJ

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Tpp1m1J/Tpp1m1J
Genetic Background: STOCK Tpp1m1J/GrsrJ

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tpp1m1J/Tpp1m1J
Genetic Background: STOCK Tpp1m1J/GrsrJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1tm1Dgen/Grm1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1.1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1.1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

Allelic Composition: Tpp1m1J/Tpp1m1J
Genetic Background: STOCK Tpp1m1J/GrsrJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1.1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1.1Plob

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1tm1Sms/Ap3b1tm1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

Allelic Composition: Tpp1tm1.1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1.1Plob

Allelic Composition: Tpp1tm1Plob/Tpp1tm1.1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob/Tpp1tm1.1Plob

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: B6.129S1-Tpp1tm1Plob

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tpp1tm1Dgen/Tpp1tm1Dgen
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011975 neuronal cytoplasmic inclusions "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [MGI:mnk]
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Allelic Composition: Tpp1m1J/Tpp1m1J
Genetic Background: STOCK Tpp1m1J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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