ENSMUSG00000031068


Mus musculus

Features
Gene ID: ENSMUSG00000031068
  
Biological name :Glrx3
  
Synonyms : Glrx3 / Glutaredoxin-3 / Q9CQM9
  
Possible biological names infered from orthology : O76003
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F4
Gene start: 137437614
Gene end: 137468594
  
Corresponding Affymetrix probe sets: 10558454 (MoGene1.0st)   1417340_at (Mouse Genome 430 2.0 Array)   1447868_x_at (Mouse Genome 430 2.0 Array)   1449726_at (Mouse Genome 430 2.0 Array)   1456244_x_at (Mouse Genome 430 2.0 Array)   1457598_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066621
Ensembl peptide - ENSMUSP00000148144
Ensembl peptide - ENSMUSP00000147891
Ensembl peptide - ENSMUSP00000147803
NCBI entrez gene - 30926     See in Manteia.
MGI - MGI:1353653
RefSeq - XM_006507916
RefSeq - NM_023140
RefSeq Peptide - NP_075629
swissprot - A0A1B0GSD3
swissprot - A0A1B0GT04
swissprot - Q9CQM9
swissprot - A0A1B0GS58
Ensembl - ENSMUSG00000031068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glrx3ENSDARG00000098785Danio rerio
 GLRX3ENSGALG00000010464Gallus gallus
 GLRX3ENSG00000108010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR004480  Monothiol glutaredoxin-related
 IPR013766  Thioredoxin domain
 IPR033658  Glutaredoxin, PICOT-like
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IMP
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0044571 [2Fe-2S] cluster assembly IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097428 protein maturation by iron-sulfur cluster transfer IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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