ENSMUSG00000031221


Mus musculus

Features
Gene ID: ENSMUSG00000031221
  
Biological name :Igbp1
  
Synonyms : Igbp1 / Immunoglobulin-binding protein 1 / Q61249
  
Possible biological names infered from orthology : AC011195.2 / P78318
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: C3
Gene start: 100494291
Gene end: 100516125
  
Corresponding Affymetrix probe sets: 10600973 (MoGene1.0st)   1419999_at (Mouse Genome 430 2.0 Array)   1420000_s_at (Mouse Genome 430 2.0 Array)   1442161_at (Mouse Genome 430 2.0 Array)   1449700_at (Mouse Genome 430 2.0 Array)   1460737_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033570
NCBI entrez gene - 18518     See in Manteia.
MGI - MGI:1346500
RefSeq - NM_008784
RefSeq Peptide - NP_032810
swissprot - Q61249
Ensembl - ENSMUSG00000031221
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igbp1ENSDARG00000002184Danio rerio
 AC011195.2ENSG00000266826Homo sapiens
 IGBP1ENSG00000089289Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igbp1bENSMUSG0000004671766


Protein motifs (from Interpro)
Interpro ID Name
 IPR007304  TAP46-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade ISO
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0035306 positive regulation of dephosphorylation IMP
 biological_processGO:0035308 negative regulation of protein dephosphorylation IDA
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060632 regulation of microtubule-based movement ISO
 biological_processGO:0070555 response to interleukin-1 ISO
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005874 microtubule IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity ISO
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IPI
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Syktm1Tyb/Syktm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Igbp1tm1Cbt/Igbp1+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Igbp1tm1Imku/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Igbp1tm1Imku/Y,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129P2/OlaHsd * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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