ENSMUSG00000031333


Mus musculus

Features
Gene ID: ENSMUSG00000031333
  
Biological name :Abcb7
  
Synonyms : Abcb7 / ATP-binding cassette, sub-family B (MDR/TAP), member 7 / Q61102
  
Possible biological names infered from orthology : ATP binding cassette subfamily B member 7 / O75027
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 104280657
Gene end: 104413856
  
Corresponding Affymetrix probe sets: 10606217 (MoGene1.0st)   1419931_at (Mouse Genome 430 2.0 Array)   1427490_at (Mouse Genome 430 2.0 Array)   1435006_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033695
NCBI entrez gene - 11306     See in Manteia.
MGI - MGI:109533
RefSeq - NM_009592
RefSeq Peptide - NP_033722
swissprot - Q61102
Ensembl - ENSMUSG00000031333
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb7ENSDARG00000062795Danio rerio
 ABCB7ENSGALG00000007788Gallus gallus
 ABCB7ENSG00000131269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb6 / Q9DC29 / ATP-binding cassette, sub-family B (MDR/TAP), member 6 / Q9NP58* / ATP binding cassette subfamily B member 6 (Langereis blood group)*ENSMUSG0000002619836


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
Mitochondrial ABC transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Vil-cre)20Syr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * DBA/2) or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2)

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Abcb7tm1.1Mdf/Y
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1btm1Ksw/Cacna1btm1Ksw
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Abcb7tm1.1Mdf/Y
Genetic Background: involves: 129S4/SvJae * FVB

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1btm1Ksw/Cacna1btm1Ksw
Genetic Background: involves: C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcb7tm1.1Mdf/Y
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

 MP:0005032 abnormal ectoplacental cone 
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Allelic Composition: Abcb7tm1.1Mdf/Y
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Vil-cre)20Syr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * DBA/2) or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Vil-cre)20Syr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * DBA/2) or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Vil-cre)20Syr/0
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6 * DBA/2) or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2)

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Abcb7tm1.1Mdf/Y
Genetic Background: involves: 129S4/SvJae * FVB

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031333 Abcb7 / Q61102 / ATP-binding cassette, sub-family B (MDR/TAP), member 7 / O75027* / ATP binding cassette subfamily B member 7*  / complex






 

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