ENSMUSG00000031352


Mus musculus

Features
Gene ID: ENSMUSG00000031352
  
Biological name :Hccs
  
Synonyms : Hccs / holocytochrome c synthetase / P53702
  
Possible biological names infered from orthology : holocytochrome c synthase / P53701
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 169250193
Gene end: 169320372
  
Corresponding Affymetrix probe sets: 10607933 (MoGene1.0st)   1420889_at (Mouse Genome 430 2.0 Array)   1420890_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033717
Ensembl peptide - ENSMUSP00000107743
Ensembl peptide - ENSMUSP00000133731
NCBI entrez gene - 15159     See in Manteia.
MGI - MGI:106911
RefSeq - XM_006528705
RefSeq - NM_001331049
RefSeq - NM_001331050
RefSeq - NM_008222
RefSeq - XM_006528703
RefSeq - XM_006528704
RefSeq Peptide - NP_032248
RefSeq Peptide - NP_001317978
RefSeq Peptide - NP_001317979
swissprot - P53702
swissprot - G3UXK7
Ensembl - ENSMUSG00000031352
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hccsa.1ENSDARG00000028131Danio rerio
 hccsa.2ENSDARG00000095776Danio rerio
 hccsbENSDARG00000099358Danio rerio
 HCCSENSGALG00000005571Gallus gallus
 HCCSENSG00000004961Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000511  Cytochrome c/c1 haem-lyase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018063 cytochrome c-heme linkage IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004408 holocytochrome-c synthase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+,Tg(CAG-EGFP)D4Nagy/0,Tg(Hmgcr-lacZ)H253Sest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hccstm1Tcc/Hccstm1Tcc,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+,Tg(CAG-EGFP)D4Nagy/0,Tg(Hmgcr-lacZ)H253Sest/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0010520 sinoatrial block "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0010636 bundle branch block "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Hccstm1Tcc/Hccs+,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Hccs+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hccstm1Tcc/Hccstm1Tcc,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Hccstm1Tcc/Y,Nkx2-5tm2(cre)Rph/Nkx2-5+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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