| MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001613 | abnormal vasodilation | "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0002376 | abnormal dendritic cell physiology | "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808] |
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Allelic Composition: Runx1tm1Spe/Runx1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0002660 | abnormal caput | "anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002673 | abnormal sperm count | "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002842 | increased blood pressure | "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Runx1tm1Spe/Runx1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0003596 | epididymal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003699 | abnormal female reproductive system physiology | "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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| MP:0005578 | teratozoospermia | "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0005616 | decreased susceptibility to type IV hypersensitivity reaction | "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008469 | abnormal protein level | "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0009233 | enlarged sperm head | "increased size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0009236 | pinhead sperm | "a sperm head that is unusually oblong in shape and much smaller than normal; typically, pinhead sperm result when the centrioles from which the sperm tails develop are not correctly aligned opposite the developing acrosome so that sperm heads are lost and absorbed during epididymal transit" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0009243 | hairpin sperm flagellum | "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0009661 | abnormal pregnancy | "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N
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