ENSMUSG00000031574


Mus musculus

Features
Gene ID: ENSMUSG00000031574
  
Biological name :Star
  
Synonyms : P51557 / Star / Steroidogenic acute regulatory protein, mitochondrial
  
Possible biological names infered from orthology : P49675 / steroidogenic acute regulatory protein
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 25806555
Gene end: 25815982
  
Corresponding Affymetrix probe sets: 10571054 (MoGene1.0st)   1418728_at (Mouse Genome 430 2.0 Array)   1418729_at (Mouse Genome 430 2.0 Array)   1430694_at (Mouse Genome 430 2.0 Array)   1449201_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148087
Ensembl peptide - ENSMUSP00000033979
NCBI entrez gene - 20845     See in Manteia.
MGI - MGI:102760
RefSeq - NM_011485
RefSeq Peptide - NP_035615
swissprot - A0A1B0GSV6
swissprot - P51557
Ensembl - ENSMUSG00000031574
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 starENSDARG00000006137Danio rerio
 STARENSGALG00000003242Gallus gallus
 STARENSG00000147465Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61542 / Stard3 / START domain containing 3 / Q14849* / StAR related lipid transfer domain containing 3*ENSMUSG0000001816732
Q9DCI3 / Stard3nl / Mus musculus STARD3 N-terminal like (Stard3nl), transcript variant 2, mRNA. / O95772* / STARD3 N-terminal like*ENSMUSG000000030626


Protein motifs (from Interpro)
Interpro ID Name
 IPR000799  Steroidogenic acute regulatory protein-like
 IPR002913  START domain
 IPR023393  START-like domain superfamily
 IPR029866  Steroidogenic acute regulatory protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006082 organic acid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006699 bile acid biosynthetic process IEA
 biological_processGO:0006703 estrogen biosynthetic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008211 glucocorticoid metabolic process IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0017085 response to insecticide IEA
 biological_processGO:0017143 insecticide metabolic process IEA
 biological_processGO:0018879 biphenyl metabolic process IEA
 biological_processGO:0018894 dibenzo-p-dioxin metabolic process IEA
 biological_processGO:0018958 phenol-containing compound metabolic process IEA
 biological_processGO:0018963 phthalate metabolic process IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032367 intracellular cholesterol transport IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0034698 response to gonadotropin IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042747 circadian sleep/wake cycle, REM sleep IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044255 cellular lipid metabolic process IMP
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IDA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0060992 response to fungicide IEA
 biological_processGO:0061370 testosterone biosynthetic process IEA
 biological_processGO:0070859 positive regulation of bile acid biosynthetic process IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071371 cellular response to gonadotropin stimulus IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0071373 cellular response to luteinizing hormone stimulus IEA
 biological_processGO:0071378 cellular response to growth hormone stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0017127 cholesterol transporter activity IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001754 increased circulating corticotropin-releasing hormone level "higher than average amount of CRH in blood; CRH is normally released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland " [J:57315]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005129 increased adrenocorticotropin level "increased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005147 prostate gland hypoplasia "reduced size of the prostate, usually due to a reduction in cell number " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005148 seminal gland hypoplasia "reduction in size, usually due to a reduction in cell number, of one of the two folded, sac shaped glands that is a diverticulum of the ductus deferens" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64337]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008299 adrenal cortical hyperplasia "overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018167 Q61542 / Stard3 / START domain containing 3 / Q14849* / StAR related lipid transfer domain containing 3*  / reaction
 ENSMUSG00000003062 Q9DCI3 / Stard3nl / Mus musculus STARD3 N-terminal like (Stard3nl), transcript variant 2, mRNA. / O95772* / STARD3 N-terminal like*  / reaction






 

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