ENSMUSG00000018167


Mus musculus

Features
Gene ID: ENSMUSG00000018167
  
Biological name :Stard3
  
Synonyms : Q61542 / Stard3 / START domain containing 3
  
Possible biological names infered from orthology : Q14849 / StAR related lipid transfer domain containing 3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98358368
Gene end: 98381112
  
Corresponding Affymetrix probe sets: 10380871 (MoGene1.0st)   1417405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018311
NCBI entrez gene - 59045     See in Manteia.
MGI - MGI:1929618
RefSeq - XM_006533897
RefSeq - NM_021547
RefSeq - XM_006533894
RefSeq - XM_006533895
RefSeq - XM_006533896
RefSeq Peptide - NP_067522
swissprot - Q544C3
swissprot - Q61542
Ensembl - ENSMUSG00000018167
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9DFS4ENSDARG00000017809Danio rerio
 STARD3ENSGALG00000014607Gallus gallus
 Q14849ENSG00000131748Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DCI3 / Stard3nl / Mus musculus STARD3 N-terminal like (Stard3nl), transcript variant 2, mRNA. / O95772* / STARD3 N-terminal like*ENSMUSG0000000306230
Star / P51557 / Steroidogenic acute regulatory protein, mitochondrial / P49675* / steroidogenic acute regulatory protein*ENSMUSG0000003157420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000799  Steroidogenic acute regulatory protein-like
 IPR002913  START domain
 IPR019498  MENTAL domain
 IPR023393  START-like domain superfamily
 IPR029867  StAR-related lipid transfer protein 3, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006701 progesterone biosynthetic process IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0099044 vesicle tethering to endoplasmic reticulum ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane ISO
 cellular_componentGO:0044232 organelle membrane contact site IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bace1tm1Bux/Bace1tm1Bux
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031574 Star / P51557 / Steroidogenic acute regulatory protein, mitochondrial / P49675* / steroidogenic acute regulatory protein*  / reaction
 ENSMUSG00000003062 Q9DCI3 / Stard3nl / Mus musculus STARD3 N-terminal like (Stard3nl), transcript variant 2, mRNA. / O95772* / STARD3 N-terminal like*  / complex






 

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