| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1
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| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0000709 | enlarged thymus | "increased size of thymus" [J:50053] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0001127 | small ovary | "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0001654 | hepatic necrosis | "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1
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| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0003131 | increased erythrocyte count | "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0003360 | depression-related behavior | |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
Allelic Composition: Asah1tm1.1Jhkh/Asah1+,Smpd1tm1Esc/Smpd1+
Genetic Background: involves: 129S1/Sv
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| MP:0004778 | increased foam cell number | "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0004952 | increased spleen weight | "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0005011 | increased eosinophil count | "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0005564 | increased hemoglobin content | "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0006396 | decreased long bone epiphyseal plate size | "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0008272 | abnormal endochondral bone ossification | "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0008647 | increased circulating interleukin-12b level | "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0008872 | abnormal response to xenobiotics | "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
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| MP:0009105 | penis prolapse | "inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0009246 | pale spleen | "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0009283 | decreased gonadal fat pad weight | "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
Allelic Composition: Asah1tm1.1Jhkh/Asah1+,Smpd1tm1Esc/Smpd1+
Genetic Background: involves: 129S1/Sv
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| MP:0010209 | abnormal circulating chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0010894 | pulmonary alveolar edema | "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Med24tm1Rgr/Med24tm1Rgr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1
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| MP:0011129 | decreased secondary ovarian follicle number | "fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith] |
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Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk
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| MP:0012232 | abnormal ceramide level | |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
Allelic Composition: Asah1tm1.1Jhkh/Asah1+,Smpd1tm1Esc/Smpd1+
Genetic Background: involves: 129S1/Sv
Allelic Composition: Asah1tm1Medin/Asah1tm1Medin
Genetic Background: involves: 129S6/SvEvTac * CD-1
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| MP:0012676 | dilated brain ventricles | "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna] |
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Allelic Composition: Asah1tm1Medin/Asah1tm1Medin
Genetic Background: involves: 129S6/SvEvTac * CD-1
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