ENSMUSG00000031629


Mus musculus

Features
Gene ID: ENSMUSG00000031629
  
Biological name :Cenpu
  
Synonyms : Cenpu / Centromere protein U / Q8C4M7
  
Possible biological names infered from orthology : Q71F23
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.1
Gene start: 46552028
Gene end: 46580007
  
Corresponding Affymetrix probe sets: 10571680 (MoGene1.0st)   1428518_at (Mouse Genome 430 2.0 Array)   1452816_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120321
Ensembl peptide - ENSMUSP00000147798
Ensembl peptide - ENSMUSP00000147789
Ensembl peptide - ENSMUSP00000147322
Ensembl peptide - ENSMUSP00000034045
Ensembl peptide - ENSMUSP00000091239
NCBI entrez gene - 71876     See in Manteia.
MGI - MGI:1919126
RefSeq - XM_006509498
RefSeq - NM_027973
RefSeq Peptide - NP_082249
swissprot - A0A1B0GS54
swissprot - D6RJ34
swissprot - Q8C4M7
swissprot - A0A1B0GS45
Ensembl - ENSMUSG00000031629
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-185e18.7ENSDARG00000088924Danio rerio
 CENPUENSGALG00000020210Gallus gallus
 CENPUENSG00000151725Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR025214  Centromere protein U


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Robo1tm1Matl/Robo1tm1Matl,Robo2tm1Rilm/Robo2tm1Rilm,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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