ENSMUSG00000031661


Mus musculus

Features
Gene ID: ENSMUSG00000031661
  
Biological name :Nkd1
  
Synonyms : Nkd1 / Protein naked cuticle homolog 1 / Q99MH6
  
Possible biological names infered from orthology : naked cuticle homolog 1 / Q969G9
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 88521354
Gene end: 88594884
  
Corresponding Affymetrix probe sets: 10573779 (MoGene1.0st)   1417278_a_at (Mouse Genome 430 2.0 Array)   1429506_at (Mouse Genome 430 2.0 Array)   1429507_at (Mouse Genome 430 2.0 Array)   1440446_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147347
Ensembl peptide - ENSMUSP00000034086
Ensembl peptide - ENSMUSP00000125935
NCBI entrez gene - 93960     See in Manteia.
MGI - MGI:2135954
RefSeq - NM_001163660
RefSeq - NM_027280
RefSeq Peptide - NP_001157132
RefSeq Peptide - NP_081556
swissprot - E9Q5K6
swissprot - Q99MH6
Ensembl - ENSMUSG00000031661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkd1ENSDARG00000020053Danio rerio
 NKD1ENSGALG00000003767Gallus gallus
 NKD1ENSG00000140807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkd2 / Q8VE28 / Mus musculus naked cuticle 2 (Nkd2), transcript variant 2, mRNA. / Q969F2* / naked cuticle homolog 2*ENSMUSG0000002156744


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IGI
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1901231 positive regulation of non-canonical Wnt signaling pathway via JNK cascade IDA
 biological_processGO:1901233 negative regulation of convergent extension involved in axis elongation IMP
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nkd1tm1Kwha/Nkd1tm1Kwha,Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Phox2a/Inppl1tm1Ssch/Inppl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myf5tm1Jae/Myf5+,Myf6tm1Eno/Myf6+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Nkd1tm1Kwha/Nkd1tm1Kwha,Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkd1tm1Kwha/Nkd1tm1Kwha,Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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