ENSMUSG00000021567


Mus musculus

Features
Gene ID: ENSMUSG00000021567
  
Biological name :Nkd2
  
Synonyms : Mus musculus naked cuticle 2 (Nkd2), transcript variant 2, mRNA. / Nkd2 / Q8VE28
  
Possible biological names infered from orthology : naked cuticle homolog 2 / Q969F2
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 73818534
Gene end: 73847631
  
Corresponding Affymetrix probe sets: 10410547 (MoGene1.0st)   1419465_at (Mouse Genome 430 2.0 Array)   1419466_at (Mouse Genome 430 2.0 Array)   1434275_at (Mouse Genome 430 2.0 Array)   1457600_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022051
Ensembl peptide - ENSMUSP00000113794
Ensembl peptide - ENSMUSP00000152231
NCBI entrez gene - 72293     See in Manteia.
MGI - MGI:1919543
RefSeq - XM_006517396
RefSeq - NM_001347535
RefSeq - NM_028186
RefSeq Peptide - NP_001334464
RefSeq Peptide - NP_082462
swissprot - Q8VE28
swissprot - A0A1Y7VJ02
Ensembl - ENSMUSG00000021567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkd2aENSDARG00000055271Danio rerio
 nkd3ENSDARG00000013174Danio rerio
 NKD2ENSG00000145506Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkd1 / Q99MH6 / Protein naked cuticle homolog 1 / Q969G9* / naked cuticle homolog 1*ENSMUSG0000003166145


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0010954 positive regulation of protein processing ISO
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IBA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0048210 Golgi vesicle fusion to target membrane ISO
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016328 lateral plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0070382 exocytic vesicle ISO
 cellular_componentGO:0071944 cell periphery ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0019838 growth factor binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0032036 myosin heavy chain binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myod1tm1Jae/Myod1tm1Jae
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nkd1tm1Kwha/Nkd1tm1Kwha,Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myf6tm1Eno/Myf6tm1Eno,Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkd1tm1Kwha/Nkd1tm1Kwha,Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkd1tm1Kwha/Nkd1tm1Kwha,Nkd2tm1Kwha/Nkd2tm1Kwha
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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