ENSMUSG00000032046


Mus musculus

Features
Gene ID: ENSMUSG00000032046
  
Biological name :Abhd12
  
Synonyms : Abhd12 / abhydrolase domain containing 12 / Q99LR1
  
Possible biological names infered from orthology : Q8N2K0
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 150832493
Gene end: 150904741
  
Corresponding Affymetrix probe sets: 10488507 (MoGene1.0st)   1417669_at (Mouse Genome 430 2.0 Array)   1453367_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122763
Ensembl peptide - ENSMUSP00000053558
Ensembl peptide - ENSMUSP00000118501
Ensembl peptide - ENSMUSP00000122331
NCBI entrez gene - 76192     See in Manteia.
MGI - MGI:1923442
RefSeq - XM_006500367
RefSeq - NM_024465
RefSeq - XM_006500365
RefSeq - XM_006500366
RefSeq Peptide - NP_077785
swissprot - Q99LR1
swissprot - F7BHM8
swissprot - D6RI21
swissprot - D6RFU2
Ensembl - ENSMUSG00000032046
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abhd12ENSDARG00000071004Danio rerio
 ABHD12ENSGALG00000008525Gallus gallus
 ABHD12ENSG00000100997Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abhd12b / abhydrolase domain containing 12B / Q7Z5M8*ENSMUSG0000009012134


Protein motifs (from Interpro)
Interpro ID Name
 IPR022742  Serine aminopeptidase, S33
 IPR026605  Monoacylglycerol lipase protein ABHD12
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002084 protein depalmitoylation IDA
 biological_processGO:0006660 phosphatidylserine catabolic process IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0010996 response to auditory stimulus IMP
 biological_processGO:0046464 acylglycerol catabolic process IEA
 biological_processGO:0046475 glycerophospholipid catabolic process IEA
 biological_processGO:0052651 monoacylglycerol catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0032839 dendrite cytoplasm IDA
 molecular_functionGO:0004622 lysophospholipase activity IEA
 molecular_functionGO:0008474 palmitoyl-(protein) hydrolase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047372 acylglycerol lipase activity IEA


Pathways (from Reactome)
Pathway description
Arachidonate production from DAG


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011579 decreased lipoprotein lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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