ENSMUSG00000032066


Mus musculus

Features
Gene ID: ENSMUSG00000032066
  
Biological name :Bco2
  
Synonyms : Bco2 / Beta,beta-carotene 9,10-oxygenase / Q99NF1
  
Possible biological names infered from orthology : beta-carotene oxygenase 2 / Q9BYV7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 50533087
Gene end: 50555181
  
Corresponding Affymetrix probe sets: 10593332 (MoGene1.0st)   1421221_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112727
NCBI entrez gene - 170752     See in Manteia.
MGI - MGI:2177469
RefSeq - XM_017313156
RefSeq - NM_133217
RefSeq - XM_006510045
RefSeq - XM_006510046
RefSeq - XM_006510047
RefSeq - XM_006510044
RefSeq Peptide - NP_573480
swissprot - Q3KNZ2
swissprot - Q99NF1
Ensembl - ENSMUSG00000032066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bco2aENSDARG00000055722Danio rerio
 bco2bENSDARG00000041715Danio rerio
 bco2lENSDARG00000027620Danio rerio
 BCO2ENSGALG00000007868Gallus gallus
 BCO2ENSG00000197580Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bco1 / Q9JJS6 / Beta,beta-carotene 15,15-dioxygenase / Q9HAY6* / beta-carotene oxygenase 1*ENSMUSG0000003184541
Rpe65 / Q91ZQ5 / Retinoid isomerohydrolase / Q16518* / RPE65, retinoid isomerohydrolase*ENSMUSG0000002817437


Protein motifs (from Interpro)
Interpro ID Name
 IPR004294  Carotenoid oxygenase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016116 carotenoid metabolic process IMP
 biological_processGO:0016119 carotene metabolic process IDA
 biological_processGO:0016121 carotene catabolic process IDA
 biological_processGO:0016122 xanthophyll metabolic process IMP
 biological_processGO:0042573 retinoic acid metabolic process NAS
 biological_processGO:0042574 retinal metabolic process NAS
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005622 intracellular IC
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0102076 beta,beta-carotene-9",10"-cleaving oxygenase activity IEA


Pathways (from Reactome)
Pathway description
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Bco2tm1Dnp/Bco2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Bco2tm1Dnp/Bco2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Tnfrsf11atm1Kost/Tnfrsf11atm1Kost
Genetic Background: involves: 129/Sv * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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