ENSMUSG00000032101


Mus musculus

Features
Gene ID: ENSMUSG00000032101
  
Biological name :Ddx25
  
Synonyms : ATP-dependent RNA helicase DDX25 / Ddx25 / Q9QY15
  
Possible biological names infered from orthology : DEAD-box helicase 25 / Q9UHL0
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 35536647
Gene end: 35558528
  
Corresponding Affymetrix probe sets: 10592140 (MoGene1.0st)   1418263_at (Mouse Genome 430 2.0 Array)   1443290_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034612
NCBI entrez gene - 30959     See in Manteia.
MGI - MGI:1353582
RefSeq - NM_013932
RefSeq Peptide - NP_038960
swissprot - Q9QY15
Ensembl - ENSMUSG00000032101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DDX25ENSG00000109832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx19a / Q61655 / ATP-dependent RNA helicase DDX19A / Q9NUU7* / DEAD-box helicase 19A*ENSMUSG0000001502353
Ddx19b / ATP-dependent RNA helicase DDX19B isoform 3 / Q9UMR2* / DEAD-box helicase 19B*ENSMUSG0000003365852


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006406 mRNA export from nucleus IDA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IDA
 biological_processGO:0008380 RNA splicing IBA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adarb1tm1Phs/Adarb1tm1Phs,Gria2tm1.1Phs/Gria2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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