ENSMUSG00000032118


Mus musculus

Features
Gene ID: ENSMUSG00000032118
  
Biological name :Fez1
  
Synonyms : Fez1 / Mus musculus fasciculation and elongation protein zeta 1 (zygin I) (Fez1), transcript variant 5, mRNA. / Q8K0X8
  
Possible biological names infered from orthology : fasciculation and elongation protein zeta 1 / Q99689
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 36821864
Gene end: 36878924
  
Corresponding Affymetrix probe sets: 10584259 (MoGene1.0st)   1454674_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124648
Ensembl peptide - ENSMUSP00000125475
Ensembl peptide - ENSMUSP00000149910
Ensembl peptide - ENSMUSP00000126072
Ensembl peptide - ENSMUSP00000034630
Ensembl peptide - ENSMUSP00000123762
Ensembl peptide - ENSMUSP00000124185
Ensembl peptide - ENSMUSP00000124634
NCBI entrez gene - 235180     See in Manteia.
MGI - MGI:2670976
RefSeq - NM_183171
RefSeq - XM_017313313
RefSeq - XM_017313312
RefSeq - XM_006510229
RefSeq - XM_006510228
RefSeq - XM_006510227
RefSeq - NM_001357613
RefSeq Peptide - NP_001344541
RefSeq Peptide - NP_001344539
RefSeq Peptide - NP_001344540
RefSeq Peptide - NP_001344542
RefSeq Peptide - NP_001344543
RefSeq Peptide - NP_898994
swissprot - E0CXY1
swissprot - Q8K0X8
swissprot - A0A1L1SSG8
swissprot - F7BWM9
swissprot - E0CYY9
swissprot - F6TRI8
swissprot - F6SG45
Ensembl - ENSMUSG00000032118
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fez1ENSDARG00000023174Danio rerio
 FEZ1ENSGALG00000038885Gallus gallus
 FEZ1ENSG00000149557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fez2 / Q6TYB5 / Fasciculation and elongation protein zeta-2 / Q9UHY8*ENSMUSG0000005612146


Protein motifs (from Interpro)
Interpro ID Name
 IPR011680  Fasciculation and elongation protein zeta, FEZ
 IPR015642  Fasciculation and elongation protein zeta 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0051654 establishment of mitochondrion localization IEA
 biological_processGO:0061881 positive regulation of anterograde axonal transport of mitochondrion IEA
 biological_processGO:0070584 mitochondrion morphogenesis IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:1902902 negative regulation of autophagosome assembly ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IBA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043015 gamma-tubulin binding IDA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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